ALKYLATING-AGENTS AND MOUSE SPERMATOGENESIS - EFFECTS OF A SINGLE DOSE OF CYCLOPHOSPHAMIDE

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dc.contributor.authorVIGIL, P
dc.contributor.authorBUSTOSOBREGON, E
dc.date.accessioned2025-01-23T19:27:38Z
dc.date.available2025-01-23T19:27:38Z
dc.date.issued1985
dc.description.abstractCyclophosphamide (CFA) is one of the alkylating agents which has now been used with some success in the treatment of human neoplasias and renal disease. To evaluate how this drug could affect the seminiferous epithelium, a single dose of CFA (200 mg/kg per wt) was given to 20 adult mice (strain A/Sw). The effect of the drug was compared with a control group to which physiological saline solution was injected. Mice were sacrificed by cervical dislocation at 4 different time intervals after the drug administration to evaluate the action of the drug in different stages of spermatogenesis. The effect of the drug was appreciated as soon as 4 days after its administration. The initial damage to the epithelium was characterized by vacuolization of the Sertoli cells. Of all germ cells, primary spermatocytes showed the highest sensitivity to the drug. A high percent of teratozoospermia in the experimental group, when compared to the control group, was observed at all time intervals. The way CFA affects the morphology of mammalian spermatozoa and the usefulness of the animal model presented are discussed.
dc.fuente.origenWOS
dc.identifier.eissn1439-0272
dc.identifier.issn0303-4569
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99750
dc.identifier.wosidWOS:A1985AKD8700010
dc.issue.numero3
dc.language.isoen
dc.pagina.final282
dc.pagina.inicio276
dc.revistaAndrologia
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleALKYLATING-AGENTS AND MOUSE SPERMATOGENESIS - EFFECTS OF A SINGLE DOSE OF CYCLOPHOSPHAMIDE
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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