ACCUMULATION OF 5-HYDROXYTRYPTAMINE BY AGING PLATELETS - STUDIES IN A MODEL OF SUPPRESSED THROMBOPOIESIS IN DOGS

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dc.contributor.authorARANDA, E
dc.contributor.authorPIZARRO, M
dc.contributor.authorPEREIRA, J
dc.contributor.authorMEZZANO, D
dc.date.accessioned2024-01-10T13:45:34Z
dc.date.available2024-01-10T13:45:34Z
dc.date.issued1994
dc.description.abstractThrombocytopenia was induced in healthy, male mongrel dogs by intramuscular injection of a single dose of estradiol valerate (1 mg/kg). A steady, almost linear decay of the blood platelet count starting about day 6 post-estradiol and attaining a mean value of 14 x 10(3) platelets/mu l one week later was observed. Thrombocytopenia is explained mainly by suppression of thrombocytopoiesis, as established by two independent ways: 1. Megakaryocytes in the bone marrow were markedly reduced. 2. Kinetic studies with In-111 labeled autologous platelets revealed a nearly linear decay of the radioactivity and mean survival times within the expected range. The progressive reduction in the platelet count is associated with an increase in the mean age of the platelets still circulating. Following estradiol injection, platelet 5-hydroxytryptamine (5-HT) increased from a basal value of 130 +/- 30 ng/10(8) platelets (platelet count of 351 +/- 53 x 10(3) platelets/mu l) to 343 +/- 100 ng/10(8) platelets eleven days latter, when the platelet count dropped to 32 +/- 18 x 10(3) platelets/mu l. No significant changes in the number or affinity of the 5-HT uptake receptors could be demonstrated in platelets exposed in vitro and in vivo to estradiol. Our results indicate that aging platelets accumulate 5-HT, probably by a sustained exposure to the monoamine in plasma, confirming previous observations based on models in which thrombopenia was induced by immune and mechanical means.
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.pubmedidMEDLINE:8052968
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79049
dc.identifier.wosidWOS:A1994NE46500015
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final492
dc.pagina.inicio488
dc.publisherGEORG THIEME VERLAG KG
dc.revistaTHROMBOSIS AND HAEMOSTASIS
dc.rightsregistro bibliográfico
dc.subjectTHROMBIN-TREATED PLATELETS
dc.subjectDENSITY SUBPOPULATIONS
dc.subjectSEROTONIN
dc.subjectKINETICS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleACCUMULATION OF 5-HYDROXYTRYPTAMINE BY AGING PLATELETS - STUDIES IN A MODEL OF SUPPRESSED THROMBOPOIESIS IN DOGS
dc.typeartículo
dc.volumen71
sipa.codpersvinculados99455
sipa.codpersvinculados99371
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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