Insights into infant behavior and development from Latin America

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dc.article.number101979
dc.contributor.authorHermida, María Julia
dc.contributor.authorNarea Biscupovich, Marigen Soledad
dc.contributor.authorSingh, Leher
dc.contributor.authorCristia, Alejandrina
dc.date.accessioned2025-05-15T10:30:05Z
dc.date.available2025-05-15T10:30:05Z
dc.date.issued2024
dc.description.abstractE-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5). BALF samples were analyzed by Luminex multiplex assay, RNA sequencing, and mass spectrometry. After treating BEAS-2B lung epithelial cells with vaping and non-vaping BALF, LDH release was quantified. THC-EVALI BALF had significant increases in IFN gamma, CCL2, CXCL5, and MMP2 relative to non-vaping patients. RNA sequencing showed enrichment for biological oxidation, glucuronidation, and fatty acid metabolism pathways. Oleic acid and arachidonic acid metabolites were increased in THC-EVALI, as were oxidized phosphatidylethanolamines (PE) such as PE(38:4). THC-EVALI BALF induced more LDH release compared to BALF from non-vaping patients. Thus, THC-EVALI is characterized by altered phospholipid composition, accumulation of lipid oxidation products, and increased pro-inflammatory mediators that may contribute to epithelial cell death. These findings serve as a framework to study novel oxidized phospholipids implicated in the pathogenesis of EVALI.
dc.description.funderNational Institutes of Health
dc.format.extent4 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.infbeh.2024.101979
dc.identifier.issn1934-8800
dc.identifier.scopusidSCOPUS_ID:85200607148
dc.identifier.urihttps://doi.org/10.1016/j.infbeh.2024.101979
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104255
dc.identifier.wosidWOS:001292065000001
dc.information.autorucEscuela de Psicología; Narea Biscupovich, Marigen Soledad; 0000-0001-7780-7425; 12649
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaInfant Behavior and Development
dc.rightsacceso restringido
dc.subjectLipidomics
dc.subjectVaping
dc.subjectAcute lung injury
dc.subjectPhospholipids
dc.subject.ddc150
dc.subject.deweyPsicologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInsights into infant behavior and development from Latin America
dc.typeartículo
dc.volumen76
sipa.codpersvinculados12649
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-05-2025
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