Laminin affects polymerization, depolymerization and neurotoxicity of Aβ peptide

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dc.contributor.authorMorgan, C
dc.contributor.authorBugueño, MP
dc.contributor.authorGarrido, J
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:30:23Z
dc.date.available2025-01-21T01:30:23Z
dc.date.issued2002
dc.description.abstractAmyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived peptide YFQRYL1 inhibits efficiently both fibril formation and neurotoxicity and show that the IKVAV peptide inhibits amyloid neurotoxicity despite its slight inhibition of fibril formation. On other hand, laminin-1 induces disaggregation of preformed fibrils in vitro, characterized as a progressive disassembly of fibrils into protofibrils and further clearance of these latter species, leading to a continual inhibition of amyloid neurotoxicity. (C) 2002 Published by Elsevier Science Inc.
dc.fuente.origenWOS
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96728
dc.identifier.wosidWOS:000177603400005
dc.issue.numero7
dc.language.isoen
dc.pagina.final1240
dc.pagina.inicio1229
dc.revistaPeptides
dc.rightsacceso restringido
dc.subjectAlzheimer
dc.subjectamyloid
dc.subjecthippocampal neurons
dc.subjectlaminin
dc.subjectneurotoxicity
dc.subjectprotofibrils
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLaminin affects polymerization, depolymerization and neurotoxicity of Aβ peptide
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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