Topical photodynamic therapy with methylaminolevulinate for the treatment of actinic keratosis and reduction of photodamage in organ transplant recipients: A case-series of 16 patients

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dc.contributor.authorHasson, Ariel
dc.contributor.authorNavarrete Dechent, Cristian
dc.contributor.authorNicklas, Claudia
dc.contributor.authorde la Cruz, Claudia
dc.date.accessioned2024-01-10T12:10:11Z
dc.date.available2024-01-10T12:10:11Z
dc.date.issued2012
dc.description.abstractBackground: Organ transplant recipients (OTR) are at high risk of developing cutaneous neoplasms. Topical photodynamic therapy (PDT) has been used for the treatment of actinic keratosis (AK) in OTR. Aims: The objective was to evaluate the efficacy of PDT with methylaminolevulinate (MAL) in the treatment of facial AK in OTR. As a secondary objective, we wanted to evaluate the usefulness of topical PDT in the reduction of photodamage in OTR. Methods: A prospective, single center, single arm study was made. 16 OTR were included. Topical PDT was applied for 1 or 2 cycles depending on the patient's characteristics. An evaluation of AK was made at visits pre-treatment, at 12 weeks and at 24 weeks. Photodamage was measured with multispectral image technique (SkinCare (R)). Results: A complete response rate of 100% was achieved for AK in all patients; it persisted without change at 12 and 24 weeks of follow-up. 62.5% of patients improved their photodamage as measured by SkinCare (R), but this result was not statistically significant (P = 0.12). All patients had high level of satisfaction at the end of the therapy. Conclusions: MAL-PDT is an effective therapy for the treatment of AK in OTRs. It can reduce photodamage in this group of patients, but these results were not statistically significant.
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4103/0378-6323.98075
dc.identifier.issn0378-6323
dc.identifier.pubmedidMEDLINE:22772615
dc.identifier.urihttps://doi.org/10.4103/0378-6323.98075
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76556
dc.identifier.wosidWOS:000306668100007
dc.information.autorucMedicina;De la Cruz C ;S/I;1001126
dc.information.autorucMedicina;Hasson A;S/I;100193
dc.information.autorucMedicina;Navarrete C ;S/I;156251
dc.information.autorucMedicina;Nicklas C ;S/I;182433
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final453
dc.pagina.inicio448
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
dc.revistaINDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
dc.rightsregistro bibliográfico
dc.subjectActinic keratosis
dc.subjectorgan transplant recipients
dc.subjectphotodamage
dc.subjectphotodynamic therapy
dc.subjectskin cancer
dc.subjecttransplant
dc.subjectSQUAMOUS-CELL CARCINOMA
dc.subjectCONTROLLED CLINICAL-TRIAL
dc.subjectNONMELANOMA SKIN-CANCER
dc.subjectGUIDELINES
dc.subjectMANAGEMENT
dc.subjectEPIDEMIOLOGY
dc.subjectEXPRESSION
dc.subjectDISEASE
dc.subjectLESIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTopical photodynamic therapy with methylaminolevulinate for the treatment of actinic keratosis and reduction of photodamage in organ transplant recipients: A case-series of 16 patients
dc.typeartículo
dc.volumen78
sipa.codpersvinculados1001126
sipa.codpersvinculados100193
sipa.codpersvinculados156251
sipa.codpersvinculados182433
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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