Structure-based characterization of multiprotein complexes

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dc.catalogadoraba
dc.contributor.authorWiederstein, M.
dc.contributor.authorGruber, M.
dc.contributor.authorFrank, K.
dc.contributor.authorMelo Ledermann, Francisco Javier
dc.contributor.authorSippl, M. J.
dc.date.accessioned2025-02-06T19:58:48Z
dc.date.available2025-02-06T19:58:48Z
dc.date.issued2014
dc.description.abstractMultiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.
dc.format.extent8 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1016/j.str.2014.05.005
dc.identifier.eissn1878-4186
dc.identifier.issn0969-2126
dc.identifier.pubmedid24954616
dc.identifier.pubmedidPMC4087271
dc.identifier.scopusid2-s2.0-84904122902
dc.identifier.urihttps://doi.org/10.1016/j.str.2014.05.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102196
dc.identifier.wosidWOS:000340487000018
dc.information.autorucFacultad de Ciencias Biológicas; Melo Ledermann, Francisco Javier; 0000-0002-0424-5991; 82342
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1070
dc.pagina.inicio1063
dc.revistaStructure (London, England : 1993)
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-ShareAlike 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject.ddc570
dc.subject.deweyBiología
dc.titleStructure-based characterization of multiprotein complexes
dc.typeartículo
dc.volumen22
sipa.codpersvinculados82342
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