Accelerated DESPOT1 with variable parameters for 3D T1 brain mapping

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dc.catalogadorvzp
dc.contributor.authorCoronado, Ronal
dc.contributor.authorVarela-Mattatall, Gabriel
dc.contributor.authorSahonero-Álvarez, Guillermo
dc.contributor.authorBotnar, René
dc.contributor.authorCecilia Besa
dc.contributor.authorIrarrázaval, Pablo
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2025-09-05T19:03:48Z
dc.date.available2025-09-05T19:03:48Z
dc.date.issued2025
dc.description.abstractPURPOSE: Driven equilibrium single pulse observation of T1 (DESPOT1) is a reliable technique for clinical 3D T1 brain mapping. However, its fixed repetition time (TR) and bandwidth (BW) and its linear modeling to estimate T1 conveys to an inefficient imaging protocol. We propose a variable DESPOT1 (vDESPOT1) acquisition and modeling strategy to improve scan efficiency and to accelerate image acquisition. METHODS: vDESPOT1 uses SPGR acquisitions with optimized combinations of TRs, BWs, and FAs, coupled with dictionary-based reconstruction to achieve faster acquisition and more efficient T1 mapping. The proposed vDESPOT1 method was compared to DESPOT1 and inversion recovery spin echo (IR-SE) in phantom and in ten brain healthy subjects. RESULTS: Results demonstrate a reduction in scan time of approximately 40 %, allowing faster 3D brain T1 mapping while maintaining accuracy and T1NR in comparison to conventional DESPOT1. Also, the computational efficiency of a pre-computed dictionary of vDESPOT1 reduces the reconstruction time by ∼50× in comparison linear regression of conventional DESPOT1. Variable BW can enhance scan efficiency without significantly affecting the SNR for T1 when using vDESPOT1. CONCLUSION: These time improvements make vDESPOT1 particularly valuable for dynamic and high-field MRI applications, such as thermal therapy monitoring, pharmacokinetic analysis in DCE-MRI, and imaging in anatomies prone to motion, including the heart, liver, and lungs.
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.mri.2025.110487
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1016/j.mri.2025.110487
dc.identifier.urihttps://kclpure.kcl.ac.uk/portal/en/publications/72ab63ae-0ca0-47d0-bd5b-021b05c93555
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105574
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Sahonero Álvarez, Guillermo; S/I; 1246202
dc.information.autorucEscuela de Ingeniería; Botnar, Rene Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Medicina; Besa Correa, Cecilia; 0000-0002-0015-0434; 167343
dc.information.autorucEscuela de Ingeniería; Irarrázaval Mena, Pablo; 0000-0002-5186-2642; 57376
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia Del Carmen; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaMagnetic Resonance Imaging
dc.rightsacceso restringido
dc.subjectSpoiled gradient echo (SPGR)
dc.subjectDriven equilibrium single pulse observation of T1 (DESPOT1)
dc.subjectVariable sequence parameters
dc.subject3D brain T1 mapping
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.titleAccelerated DESPOT1 with variable parameters for 3D T1 brain mapping
dc.typeartículo
dc.volumen123
sipa.codpersvinculados1246202
sipa.codpersvinculados1015313
sipa.codpersvinculados167343
sipa.codpersvinculados57376
sipa.codpersvinculados14195
sipa.trazabilidadORCID;2025-09-01
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