Plasma 18-hydroxycortisol as screening test in aldosteronism

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dc.contributor.authorMosso, L
dc.contributor.authorGomez Sanchez, C
dc.contributor.authorFoecking, M
dc.contributor.authorFardella, C
dc.date.accessioned2024-08-15T08:00:08Z
dc.date.available2024-08-15T08:00:08Z
dc.date.issued2001
dc.description.abstractBackground: Thyroid microcarcinoma is a tumor of 10 mm or less. that should have a low risk of mortality. However a subgroup of these carcinomas is as aggressive as bigger tumors. Aim To describe the pathological presentation of these tumors.. and compare them with larger tumors. Material and methods. All Pathological samples of thyroid carcinoma that were obtained between 1992 and 2003, were studied. In all biopsies, the pathological type, tumor size. the focal or multifocal character the presence of lymph node involvement and the presence of lymphocytic thyroiditis or thyroid hyperplasia, were recorded. Results: One hundred eighteen microcarcinomas and 284 larger tumors were studied. The mean age of patients with microcarcinoma and larger tumors was 42.7 +/- 14 and 49.3 +/- 16 years respectively (p < 0,00.1) and 83% were female. without gender differences between tumor types. klean size of microcarcinomas was 8.6 mm and 116 (98%) were papillary carcinomas. Of these. 109 (94% were well differentiated and seven (6%) were moderatly differentiated. Thirty six(31%) were multifocal and in 10 (8,6%), there was lymph node involvement. The mean size of larger tumors was 23.8 mm and 241 (85%) were papillary carcinomas. Of these, 200 (83%) were well differentiated, and 41 (17%) were moderately differentiated.Eighty five (35%) were multifocal and in 44 (18%) there was lymph node involvement. The prevalence of thyroiditis and hyperplasia was significantly higher among microcardinomas than in larger tumors (15 and 2.5%, respectively, p < 0.001, for the former; 32.4 and 1.7%, respectively, p < 0.001, for the latter. Conclusions. In this series. one third of microcarcinomas were multifocal and 10% had lymph node involvement. Therefore, aggresiveness of these tumors is higher than what is reported in the literature and they should be treated with total thyroidectomy.
dc.format.extent1 página
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:16446853
dc.identifier.scopusidSCOPUS_ID:0033155140
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87444
dc.identifier.wosidWOS:000167748000196
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1027
dc.pagina.inicio1027
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectneoplasms
dc.subjectglandular and epithelial
dc.subjectthyroid neoplasms
dc.subjectthyroidectomy
dc.subjectLYMPH-NODE METASTASIS
dc.subjectPAPILLARY
dc.subjectRECURRENCE
dc.subjectNODULES
dc.subjectTUMORS
dc.titlePlasma 18-hydroxycortisol as screening test in aldosteronism
dc.typecomunicación de congreso
dc.volumen37
sipa.codpersvinculados88201
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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