Comparison of different methods to estimate glomerular filtration rate in older adults¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?

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dc.article.number100714
dc.contributor.authorVega J.
dc.contributor.authorHuidobro E J.P.
dc.contributor.authorSepulveda R.A.
dc.date.accessioned2025-05-01T10:30:42Z
dc.date.available2025-05-01T10:30:42Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians. AIM: To compare GFR estimated (eGFR) with the available equations and measured CrCl in patients ≥ 70 years. A secondary aim was to know the differences in chronic kidney disease (CKD) classification, when using the different eGFR formulas. PATIENTS AND METHODS: In 144 patients aged 77 ± 5 years (58% men), CrCl was measured and GFR was estimated using MDRD, CKD-EPI, BIS-1 and FAS formulas. The eGFR and the stage of CKD were compared according to the different equations used. RESULTS: GFR estimated by MDRD and CKD-EPI equations was 7.8 and 8.4 mL/min/1.73 m2 lower than 24-hour ClCr, respectively. This difference was even greater using the BIS-1 and FAS equations. Twenty-four-hour CrCl classified 47.2% of the patients in a category of renal function > 60 mL/min/1.73 m2, while MDRD and CKD-EPI equations classified just over a third, and BIS-1 and FAS formulas around 20% of the patients. CONCLUSIONS: The practice of considering equivalent the GFR estimation using the creatinine-based equations with measured creatinine clearance in older adults should be reconsidered, because their results differ markedly.
dc.description.funderANID
dc.description.funderANID CONCYTEC
dc.description.funderANID FONDECYT
dc.description.funderJavier Gasulla
dc.description.funderRed Salud UC-CHRISTUS
dc.description.funderNational Institutes of Health NIAID
dc.description.funderUBA
dc.format.extent195 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0034-98872021000200187
dc.identifier.eissn07176163
dc.identifier.issn07176163
dc.identifier.pubmedid34479262
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85115755472
dc.identifier.urihttps://doi.org/10.4067/s0034-98872021000200187
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103652
dc.identifier.wosidWOS:000808824400017
dc.information.autorucEscuela de Medicina; Sepulveda Palamara Rodrigo Andres; 0000-0002-9618-3686; 252768
dc.information.autorucEscuela de Medicina; Huidobro Espinosa Juan Pablo; 0000-0002-5717-1017; 149948
dc.issue.numero2
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final195
dc.pagina.inicio187
dc.relation.ispartofRevista medica de Chile
dc.revistaRevista medica de Chile
dc.rightsAcceso abierto
dc.subjectBiomarkers, Tumor
dc.subjectMalignant Carcinoid Syndrome
dc.subjectNeuroendocrine Tumors
dc.subjectSomatostatin
dc.subject.ddc400
dc.subject.deweyLenguases_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleComparison of different methods to estimate glomerular filtration rate in older adults¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
dc.typeartículo
dc.volumen149
sipa.codpersvinculados252768
sipa.codpersvinculados149948
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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