Enhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Coronary Heart Disease

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dc.article.number1164357
dc.contributor.authorBravo L.
dc.contributor.authorPereyra K.V.
dc.contributor.authorDiaz H.S.
dc.contributor.authorFlores M.
dc.contributor.authorSchwarz K.G.
dc.contributor.authorToledo C.
dc.contributor.authorDiaz-Jara E.
dc.contributor.authorGonzalez L.
dc.contributor.authorAndia M.E.
dc.contributor.authorDel Rio R.
dc.contributor.otherCEDEUS (Chile)
dc.date.accessioned2025-05-01T10:33:07Z
dc.date.available2025-05-01T10:33:07Z
dc.date.issued2023
dc.description.abstract© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.Coronary heart disease (CHD) is a prevalent cardiovascular disease characterized by coronary artery blood flow reductions caused by lipid deposition and oxidation within the coronary arteries. Dyslipidemia is associated with local tissue damage by oxidative stress/inflammation and carotid bodies (CB) peripheral chemoreceptors are heavily modulated by both reactive oxygen species and pro-inflammatory molecules (i.e., cytokines). Despite this, it is not know whether CB-mediated chemoreflex drive may be affected in CHD. In the present study, we evaluated peripheral CB-mediated chemoreflex drive, cardiac autonomic function, and the incidence of breathing disorders in a murine model of CHD. Compared to age-matched control mice, CHD mice showed enhanced CB-chemoreflex drive (twofold increase in the hypoxic ventilatory response), cardiac sympathoexcitation, and irregular breathing disorders. Remarkably, all these were closely linked to the enhanced CB-mediated chemoreflex drive. Our results showed that mice with CHD displayed an enhanced CB chemoreflex, sympathoexcitation, and disordered breathing and suggest that CBs may be involved in chronic cardiorespiratory alterations in the setting of CHD.
dc.description.funderNational Agency for Research and Development
dc.description.funderFondecyt
dc.description.funderANID
dc.format.extent11 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1007/978-3-031-32371-3_11
dc.identifier.eisbn9780128194706
dc.identifier.eissn1549-7828
dc.identifier.isbn9783031764011
dc.identifier.issn00652598
dc.identifier.pubmedid40156360
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85163270324
dc.identifier.urihttps://doi.org/10.1007/978-3-031-32371-3_11
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103953
dc.identifier.wosidWOS:001159473800012
dc.information.autorucEscuela de Medicina; Andia Kohnenkampf Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.information.autorucFacultad de Ciencias Biológicas; Del Rio Troncoso Rodrigo Andre; 0000-0003-0315-6660; 126608
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final106
dc.pagina.inicio99
dc.publisherSpringer
dc.relation.ispartofIntersections Interdisciplinary Research on Architecture, Design, City and Territory
dc.revistaAdvances in experimental medicine and biology
dc.rightsacceso restringido
dc.subjectApoliprotein E
dc.subjectAtherosclerosis
dc.subjectCarotid body
dc.subjectCoronary heart disease
dc.subjectHypomorphic
dc.subjectScavenger receptor class B type 1
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleEnhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Coronary Heart Disease
dc.typeartículo
dc.volumen1427
sipa.codpersvinculados90691
sipa.codpersvinculados126608
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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