PYRAMIDAL NEURONS OF THE RAT CEREBRAL-CORTEX, IMMUNOREACTIVE TO NICOTINIC ACETYLCHOLINE-RECEPTORS, PROJECT MAINLY TO SUBCORTICAL TARGETS

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dc.contributor.authorBRAVO, H
dc.contributor.authorKARTEN, HJ
dc.date.accessioned2025-01-23T19:22:07Z
dc.date.available2025-01-23T19:22:07Z
dc.date.issued1992
dc.description.abstractCortical neurons immunoreactive to nicotinic acetylcholine receptors (nAChR) of the rat brain were characterized with monoclonal antibodies directed to ACh-binding subunits (alpha 4) or to ACh-structural subunits (beta2). A heterogeneous population of nAChR-LI neurons was found in all cortical regions. The most prominent immunoreactive neurons were pyramids of layers V and II-III. The nonpyramidal positive neurons were fusiform horizontally oriented neurons of layer VIb, small cells of layer I and round or ovoid neurons of layers II-V.
dc.description.abstractDouble labeled experiments (immunohistochemistry and fluorescent retrograde tracers) showed that cholinoceptive pyramidal neurons of layer V project mainly to subcortical targets such as caudate-putamen, superior colliculus, and pontine nuclei, while very few nAChR positive neurons connect to other cortical areas. These findings suggest that the mainly excitatory effect that has been attributed to the cholinergic innervation upon the cortical neurons may have a greater influence upon the cortico-subcortical output than the cortico-cortical one.
dc.fuente.origenWOS
dc.identifier.issn0021-9967
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98968
dc.identifier.wosidWOS:A1992HU90900003
dc.issue.numero1
dc.language.isoen
dc.pagina.final68
dc.pagina.inicio62
dc.revistaJournal of comparative neurology
dc.rightsacceso restringido
dc.subjectCEREBRAL CORTEX
dc.subjectCHOLINOCEPTIVE NEURONS
dc.subjectIMMUNOHISTOCHEMISTRY
dc.subjectRED BEADS
dc.subjectPATHWAYS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePYRAMIDAL NEURONS OF THE RAT CEREBRAL-CORTEX, IMMUNOREACTIVE TO NICOTINIC ACETYLCHOLINE-RECEPTORS, PROJECT MAINLY TO SUBCORTICAL TARGETS
dc.typeartículo
dc.volumen320
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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