Right hemisphere engagement in language abilities in older adults: indication of compensation rather than decline

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dc.article.number1458692
dc.catalogadorjlo
dc.contributor.authorSolomons, Daniel
dc.contributor.authorRodríguez Fernández, María
dc.contributor.authorMery Muñoz, Francisco Javier
dc.contributor.authorArraño Carrasco, Leonardo Marcelo
dc.contributor.authorToloza Ramírez, David Isaias
dc.contributor.authorSahli Costabal, Francisco
dc.contributor.authorMéndez Orellana, Carolina Patricia
dc.date.accessioned2025-12-30T14:29:57Z
dc.date.available2025-12-30T14:29:57Z
dc.date.issued2025
dc.description.abstractIntroduction: Structural brain changes during aging have been used as specific markers to distinguish normal aging from dementia. Changes in specific cognitive abilities such as episodic memory, processing speed, and executive functions, are observed in healthy aging. Limited evidence reports changes in linguistic functions alongside structural and functional brain changes. This study investigates correlations between language performance, gray matter volume (GMV), and neural activity in language regions, adjusted for demographic factors, in healthy older adults. Methods: Twenty-seven right-handed participants aged 60–87 were evaluated for overall linguistic performance using the Spanish version of ScreeLing (SCL) test and phonemic fluency and semantic verbal fluency tasks (PF and SF). Participants also underwent an MRI session during which they performed a functional MRI language task. T1-weighted MRI scans were used to measure GMV in specific language-related regions and assess language lateralization. Correlational analyses were conducted between language scores, GMV, years of education, age, sex, and fMRI lateralization. Results: In the right hemisphere (RH), significant positive correlations were found between SCL scores and GMV in the orbital inferior frontal gyrus (r = 0.5402; p = 0.0044) and the superior temporal gyrus (r = 0.516; p = 0.007). Furthermore, SCL and Phonemic fluency positively correlated with years of education, indicating that higher education enhances speech performance. No significant correlations were found in the left hemisphere (LH). Age, sex, and fMRI lateralization did not significantly correlate with specific linguistic scores. Discussion: These results challenge the current view of the role of the right hemisphere in language performance as increased GMV in specific right hemisphere language regions is associated with better language performance, highlighting the role of the right hemisphere in supporting language skills during healthy aging.
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2025-12-30
dc.format.extent10 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.3389/fragi.2025.1458692
dc.identifier.eissn2673-6217
dc.identifier.issn2673-6217
dc.identifier.scopusidSCOPUS_ID:105008097264
dc.identifier.urihttp://doi.org/10.3389/fragi.2025.1458692
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107507
dc.identifier.wosidWOS:001508526100001
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Solomons, Daniel; S/I; 1140658
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Rodríguez Fernández, María; 0000-0003-1966-2920; 1031920
dc.information.autorucEscuela de Medicina; Mery Muñoz, Francisco Javier; S/I; 3633
dc.information.autorucEscuela de Medicina; Arraño Carrasco Leonardo Marcelo; S/I; 167342
dc.information.autorucEscuela de Medicina; Toloza Ramírez, David Isaias; S/I; 1186482
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Sahli Costabal, Francisco; 0000-0002-2612-463X; 154857
dc.information.autorucEscuela de Medicina; Méndez Orellana, Carolina Patricia; 0000-0001-5217-9725; 1015155
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaFrontiers in Aging
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAging
dc.subjectGray matter volume
dc.subjectLanguage lateralization
dc.subjectMagnetic resonance imaging
dc.subjectPhonological
dc.subjectSemantic
dc.subjectSyntactic
dc.subjectVerbal fluency
dc.subject.ddc610
dc.subject.ods04 Quality education
dc.subject.ods03 Good health and well-being
dc.subject.odspa04 Educación y calidad
dc.subject.odspa03 Salud y bienestar
dc.titleRight hemisphere engagement in language abilities in older adults: indication of compensation rather than decline
dc.typeartículo
dc.volumen6
sipa.codpersvinculados1140658
sipa.codpersvinculados1031920
sipa.codpersvinculados3633
sipa.codpersvinculados167342
sipa.codpersvinculados1186482
sipa.codpersvinculados154857
sipa.codpersvinculados1015155
sipa.trazabilidadSCOPUS;2025-06-22
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