Extracellular vesicle production by oral bacteria related to dental caries and periodontal disease: role in microbe-host and interspecies interactions

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dc.catalogadorpau
dc.contributor.authorLeiva Sabadini, Camila
dc.contributor.authorSaavedra, Paula
dc.contributor.authorInostroza, Carla
dc.contributor.authorAguayo, Sebastian
dc.date.accessioned2025-04-10T19:09:06Z
dc.date.available2025-04-10T19:09:06Z
dc.date.issued2024
dc.description.abstract© 2024 Informa UK Limited, trading as Taylor & Francis Group.Extracellular vesicles (EVs) are cell membrane-derived structures between 20-400 nm in size. In bacteria, EVs play a crucial role in molecule secretion, cell wall biogenesis, cell-cell communication, biofilm development, and host-pathogen interactions. Despite these increasing reports of bacterial-derived vesicles, there remains a limited number of studies that summarize oral bacterial EVs, their cargo, and their main biological functions. Therefore, the aim of this review is to present the latest research on oral bacteria-derived EVs and how they can modulate various physiological and pathological processes in the oral cavity, including the pathogenesis of highly relevant diseases such as dental caries and periodontitis and their systemic complications. Overall, caries-associated bacteria (such as Streptococcus mutans) as well as periodontal pathogens (including the red complex pathogens Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) have all been shown to produce EVs that carry an array of virulent factors and molecules involved in biofilm and immune modulation, bacterial adhesion, and extracellular matrix degradation. As bacterial EV production is strongly impacted by genotypic and environmental variations, the inhibition of EV genesis and secretion remains a key potential future approach against oral diseases.
dc.fuente.origenSCOPUS
dc.identifier.doi10.1080/1040841X.2024.2427656
dc.identifier.issn1549-7828
dc.identifier.scopusidSCOPUS_ID:85210038674
dc.identifier.urihttps://doi.org/10.1080/1040841X.2024.2427656
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103197
dc.identifier.wosidWOS:001359348300001
dc.information.autorucFacultad de Ciencias Biológicas; Leiva Sabadini, Camila; S/I; 1027766
dc.information.autorucFacultad de Ciencias Biológicas; Saavedra, Paula; S/I; 1028068
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Aguayo, Sebastian; 0000-0003-0900-1993; 1062336
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherTaylor and Francis Ltd.
dc.revistaCritical Reviews in Microbiology
dc.rightsacceso restringido
dc.subjectExtracellular vesicles
dc.subjectOral biofilm
dc.subjectOral streptococci
dc.subjectPorphyromonas gingivalis
dc.subjectStreptococcus mutans
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracellular vesicle production by oral bacteria related to dental caries and periodontal disease: role in microbe-host and interspecies interactions
dc.typeartículo
sipa.codpersvinculados1027766
sipa.codpersvinculados1028068
sipa.codpersvinculados1062336
sipa.trazabilidadSCOPUS;2024-12-08
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