Crohn's disease patients carrying <i>Nod2</i>/<i>CARD15</i> gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence

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dc.contributor.authorAlvarez-Lobos, M
dc.contributor.authorArostegui, JI
dc.contributor.authorSans, M
dc.contributor.authorTassies, D
dc.contributor.authorPlaza, S
dc.contributor.authorDelgado, S
dc.contributor.authorLacy, AM
dc.contributor.authorPique, JM
dc.contributor.authorYagüe, J
dc.contributor.authorPanés, J
dc.date.accessioned2025-01-21T01:06:40Z
dc.date.available2025-01-21T01:06:40Z
dc.date.issued2005
dc.description.abstractObjective: To study the predictive value of Nod2/CARD15 gene variants along with disease phenotypic characteristics for requirement of initial surgery and for surgical recurrence in Crohn's disease (CD).
dc.description.abstractSummary Background Data: Nod2/CARD15 gene variants play an important role in the susceptibility to CD. Studies of genotype-phenotype relationship suggest that these variants are associated with development of intestinal strictures. Preliminary reports analyzing the association between these variants and need for si have produced inconsistent results.
dc.description.abstractMethods: A total of 170 CD patients were included prospectively in the study and followed up regularly for a rnean of 7.4 +/- 6.1 years. Clinical characteristics of CD, time and indication for surgery, and recurrence were registered. Nod2/CARD15 gene variants were determined by DNA sequencing analysis.
dc.description.abstractResults: Surgery for stricturing disease was significantly more frequent in patients with Nod2/CARD15 variants in the univariate analysis (odds ratio [OR], 3.63; 95% confidence interval [CI], 1.42-9.27), and it was required at an earlier time (P = 0.004). Only Nod2/CARD15 variants (OR, 3.58; 95% Cl, 1.21-10.5) and stricturing phenotype at diagnosis of CD (OR, 9.34; 95% Cl, 2.56-33.3) were independent predictive factors of initial Surgery for stricturing lesions in the multivariate analysis. Among 70 patients that required surgery, postoperative recurrence was also more frequent in patients with Nod2/CARD15 variants in the univariate and multivariate analysis (OR, 3.29; 95% Cl, 1.13-9.56), and reoperation was needed at ail earlier time (P = 0.03).
dc.description.abstractConclusion: Nod2/CARD15 variants are associated with early initial surgery due to stenosis and with surgical recurrence in Crohn's disease. Patients with these variants could benefit from preventive and/or early therapeutic strategies.
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.sla.0000186173.14696.ea
dc.identifier.eissn1528-1140
dc.identifier.issn0003-4932
dc.identifier.urihttps://doi.org/10.1097/01.sla.0000186173.14696.ea
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96200
dc.identifier.wosidWOS:000233215500012
dc.issue.numero5
dc.language.isoen
dc.pagina.final700
dc.pagina.inicio693
dc.revistaAnnals of surgery
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCrohn's disease patients carrying <i>Nod2</i>/<i>CARD15</i> gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence
dc.typeartículo
dc.volumen242
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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