Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation

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dc.contributor.authorCabrera, Daniel
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorSolis, Nancy
dc.contributor.authorSan Martin, Diego
dc.contributor.authorCofre, Catalina
dc.contributor.authorPizarro, Margarita
dc.contributor.authorPablo Arab, Juan
dc.contributor.authorAbrigo, Johanna
dc.contributor.authorCampos, Fabian
dc.contributor.authorIrigoyen, Betzabe
dc.contributor.authorCarrasco-Avino, Gonzalo
dc.contributor.authorBezares, Katiuska
dc.contributor.authorRiquelme, Valentina
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorArrese, Marco
dc.contributor.authorBarrera, Francisco
dc.date.accessioned2025-01-23T21:22:39Z
dc.date.available2025-01-23T21:22:39Z
dc.date.issued2018
dc.description.abstractBackground: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile and muscle function in an NAFLD model. Methods: C57BL/6 mice were fed with a high fat diet (HFD) for 12 weeks and were separated into three groups treated for 4 weeks with: (1) High fat diet (HFD) (n = 10); (2) HFD + GH 9 g/g/d (n = 10); (3) HFD + IGF-1 0.02 mu g/g/d (n = 9). A control group fed a chow diet was included (n = 6). Liver histology, liver triglycerides content, serum alanine aminotransferase (ALT) activity, adiponectin and leptin serum levels, in vivo muscle strength, tetanic force and muscle fibre cross-sectional area (CSA) were measured. Results: HFD + GH and HFD + IGF-1 groups showed significantly lower ALT activity compared to HFD (p < 0.01). Liver triglyceride content in HFD + GH was decreased compared to HFD (p < 0.01). Histologic steatosis score was increased in HFD and HFD + GH group (p < 0.01), whereas HFD + IGF-1 presented no difference compared to the chow group (p = 0.3). HFD + GH group presented lower serum leptin and adiponectin levels compared to HFD. GH and IGF-1 supplementation therapy reverted HFD-induced reduction in muscle strength and CSA (sarcopenia). Conclusions: GH and IGF-1 supplementation induced significant improvement in liver steatosis, aminotransferases and sarcopenia in a diet-induced NAFLD model.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms19051339
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms19051339
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101260
dc.identifier.wosidWOS:000435297000075
dc.issue.numero5
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectfatty liver
dc.subjectsomatotropic axis
dc.subjectgrowth hormone
dc.subjectinsulin growth factor 1
dc.subjectIGF-1
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSomatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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