EFFECT OF INTRAVENOUS DIPYRIDAMOLE ON REGIONAL CORONARY BLOOD-FLOW WITH 1-VESSEL CORONARY-ARTERY DISEASE - EVIDENCE AGAINST CORONARY STEAL

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dc.contributor.authorMARCHANT, E
dc.contributor.authorPICHARD, AD
dc.contributor.authorCASANEGRA, P
dc.contributor.authorLINDSAY, J
dc.date.accessioned2025-01-23T19:43:48Z
dc.date.available2025-01-23T19:43:48Z
dc.date.issued1984
dc.description.abstractThe effects of i.v. dipyridamole were studied in 9 patients with isolated total left anterior descending coronary artery (LAD) obstruction, in 6 patients with isolated 90-99% diameter reduction of the LAD and in 10 patients with normal coronary arteries and normal left ventricular function. Coronary sinus and great cardiac vein flows were determined by continuous thermodilution. Flows were measured at rest and 1, 3, 5 and 10 min after i.v. dipyridamole. Great cardiac vein flow represents the venous outflow from the LAD territory. In the presence of coronary steal from the LAD territory, great cardiac vein flow is expected to decrease while coronary sinus flow increases. I.v. dipyridamole induced a similar flow increase in the coronary sinus and the great cardiac vein in all 3 groups (P < 0.001 between rest and dipyridamole, difference not significant among groups), suggesting that no coronary steal was induced. The maximal increase in great cardiac vein flow was 118 .+-. 74% in the control group, 86 .+-. 74% in the group with 90-99% LAD obstruction and 102 .+-. 29% in the group with total LAD obstruction (difference not significant). Evidently, i.v. dipyridamole produces a similar increase in coronary flow in ischemic and nonischemic areas and an increase in collateral flow is the underlying mechanism for increased flow to the ischemic area.
dc.fuente.origenWOS
dc.identifier.eissn1879-1913
dc.identifier.issn0002-9149
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99826
dc.identifier.wosidWOS:A1984SG55500013
dc.issue.numero6
dc.language.isoen
dc.pagina.final721
dc.pagina.inicio718
dc.revistaAmerican journal of cardiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF INTRAVENOUS DIPYRIDAMOLE ON REGIONAL CORONARY BLOOD-FLOW WITH 1-VESSEL CORONARY-ARTERY DISEASE - EVIDENCE AGAINST CORONARY STEAL
dc.typeartículo
dc.volumen53
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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