Biotechnology applied to<i>Haematococcus pluvialis</i>Fotow: challenges and prospects for the enhancement of astaxanthin accumulation

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dc.contributor.authorLe-Feuvre, Regis
dc.contributor.authorMoraga-Suazo, Priscila
dc.contributor.authorGonzalez, Javiera
dc.contributor.authorMartin, Sergio San
dc.contributor.authorHenriquez, Vitalia
dc.contributor.authorDonoso, Andrea
dc.contributor.authorAgurto-Munoz, Cristian
dc.date.accessioned2025-01-23T19:48:03Z
dc.date.available2025-01-23T19:48:03Z
dc.date.issued2020
dc.description.abstractAmong natural sources, the green algaHaematococcus pluvialisis the major producer of the potent antioxidant pigment astaxanthin, a high-value compound whose demand is still not sufficiently covered by the current industrial production. Despite the availability of low-cost synthetic astaxanthin, natural astaxanthin is more potent and accepted for human consumption and food additive uses. This review highlights the use of different biotechnological approaches aiming to increase astaxanthin production yields and discusses the advantages and drawbacks of traditional alternatives widely used on other microorganisms. These traditional approaches span from the easy to perform but not devoid of problems random mutagenesis, to advanced methods like microalgae genetic engineering, which has great potential for enhancement, despite being highly restricted in several countries by genetically modified organism legislation. In addition, we propose the underexplored approach of artificial polyploidization for the obtention of strains with increased cell size, which have the advantage of being considered as non-genetically modified organisms that do not require modification of the current industrial production procedures.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo de Chile - Chilean Fondo de Fomento al Desarrollo Cientifico y Tecnologico (FONDEF)
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10811-020-02231-z
dc.identifier.eissn1573-5176
dc.identifier.issn0921-8971
dc.identifier.urihttps://doi.org/10.1007/s10811-020-02231-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100423
dc.identifier.wosidWOS:000572023600001
dc.issue.numero6
dc.language.isoen
dc.pagina.final3852
dc.pagina.inicio3831
dc.revistaJournal of applied phycology
dc.rightsacceso restringido
dc.subjectHaematococcus pluvialis
dc.subjectHaematococcus lacustris
dc.subjectAntioxidant
dc.subjectGenetic engineering
dc.subjectClassical mutagenesis
dc.subjectPolyploidy
dc.subject.ods06 Clean Water and Sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleBiotechnology applied to<i>Haematococcus pluvialis</i>Fotow: challenges and prospects for the enhancement of astaxanthin accumulation
dc.typeartículo
dc.volumen32
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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