VISIBLE-LIGHT EFFECTS ON TUMORAL CELLS IN A CULTURE-MEDIUM ENRICHED WITH TRYPTOPHAN AND RIBOFLAVIN

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dc.contributor.authorEDWARDS, AM
dc.contributor.authorSILVA, E
dc.contributor.authorJOFRE, B
dc.contributor.authorBECKER, MI
dc.contributor.authorDEIOANNES, AE
dc.date.accessioned2025-01-21T01:35:20Z
dc.date.available2025-01-21T01:35:20Z
dc.date.issued1994
dc.description.abstractWhen NSO/2 myeloid cell line and teratocarcinoma F9 cells were irradiated in Dulbecco's modified Eagle medium enriched with tryptophan and riboflavin, toxic photoproducts for these tumoral cells were generated. The active participation of O-1(2) and .OH was established using specific scavengers and quenchers. A cytotoxic effect was also observed when unirradiated tumoral cells were incubated in a previously irradiated culture medium enriched with tryptophan and riboflavin. When irradiated medium was used alone, enriched only with tryptophan or only with riboflavin, no toxic effect was observed. The relevance of charge transfer processes between triplet riboflavin and tryptophan in the generation of cytotoxic photoproducts is discussed.
dc.fuente.origenWOS
dc.identifier.issn1011-1344
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97668
dc.identifier.wosidWOS:A1994PH77800005
dc.issue.numero3
dc.language.isoen
dc.pagina.final186
dc.pagina.inicio179
dc.revistaJournal of photochemistry and photobiology b-biology
dc.rightsacceso restringido
dc.subjectCYTOTOXICITY
dc.subjectTUMORAL CELLS
dc.subjectRIBOFLAVIN
dc.subjectTRYPTOPHAN
dc.subjectIRRADIATION
dc.subjectOXYGEN REACTIVE SPECIES
dc.subjectTRANSMISSION ELECTRON MICROSCOPY
dc.subjectAPOPTOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVISIBLE-LIGHT EFFECTS ON TUMORAL CELLS IN A CULTURE-MEDIUM ENRICHED WITH TRYPTOPHAN AND RIBOFLAVIN
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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