Subjective cognitive complaints and cognitive decline in the MAUCO population-based prospective cohort

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dc.catalogadorvzp
dc.contributor.authorLeniz Martelli, Javiera
dc.contributor.authorHuidobro, Laura A.
dc.contributor.authorCortés Arancibia, Sandra
dc.contributor.authorBambs S., Claudia
dc.contributor.authorFerreccio Readi, Fresia Catterina
dc.contributor.authorToro, Pablo
dc.date.accessioned2026-01-12T14:28:53Z
dc.date.available2026-01-12T14:28:53Z
dc.date.issued2026
dc.description.abstractBackgroundSubjective cognitive complaints (SCC) have been identified as potentially prodromal to dementia and Alzheimer's disease but research in Latin American populations is lacking.ObjectiveTo analyze sociodemographic and clinical factors associated with incidence of SCC and cognitive decline in Chile.MethodsA prospective population-based study in a central-south county of Chile: the MAUCO cohort. We included adults (38–74 years) with a SCC questionnaire and Mini-Mental State Examination (MMSE) test at baseline and follow-up, and normal baseline cognitive assessments. Multivariate Cox regression was used to assess associations between sociodemographic, clinical factors and incidence of SCC and cognitive decline.Results2136 participants had cognitive assessments at baseline and follow-up. Average age was 56 years (SD 9.13), 76% female, 25% had <6 years of education. Mean follow-up was 5.0 (SD 0.64) years. Among 1504 participants without baseline SCC, 254 (16.8%) reported SCC at follow-up. Older age (HR 1.02; 95% CI 1.01–1.03), use of benzodiazepines (HR 2.14; 95% CI 1.27–3.61), antidepressants (HR 1.88; 95% CI 1.07–3.30) or depressive symptoms (HR 1.60; 95% CI 1.19–2.15) were associated to SCC incidence. Of 1646 with a normal baseline MMSE, 208 (12.6%) developed cognitive decline. The number of medications (HR 1.11; 95% CI 1.03–1.20), and baseline SCC (HR 1.40; 95% CI 1.05–1.88) were associated with cognitive decline.ConclusionsUse of benzodiazepines and antidepressants were the main factors associated with SCC, while SCC and MMSE score were the strongest predictors of cognitive decline. Both should be used to target preventive interventions.
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1177/13872877251406622
dc.identifier.eissn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttps://doi.org/10.1177/13872877251406622
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107631
dc.information.autorucEscuela de Medicina; Leniz Martelli, Javiera; 0000-0002-9315-4871; 16027
dc.information.autorucEscuela de Medicina; Cortes Arancibia, Sandra Isabel; 0000-0003-3293-1419; 1005970
dc.information.autorucEscuela de Medicina; Bambs Sandoval, Claudia Elena; 0000-0002-7043-6833; 89631
dc.information.autorucEscuela de Medicina; Ferreccio Readi, Fresia Catterina; 0000-0001-6331-5534; 99684
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaJOURNAL OF ALZHEIMERS DISEASE
dc.rightsacceso restringido
dc.subjectAlzheimer’s disease
dc.subjectCognitive decline
dc.subjectCognitive impairment
dc.subjectRisk factors
dc.subjectSubjective cognitive complaint
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSubjective cognitive complaints and cognitive decline in the MAUCO population-based prospective cohort
dc.typeartículo
sipa.codpersvinculados16027
sipa.codpersvinculados1005970
sipa.codpersvinculados89631
sipa.codpersvinculados99684
sipa.trazabilidadORCID;2026-01-05
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