Overexpression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients

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dc.contributor.authorBaudrand, Rene
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorMorales, Mauricio
dc.contributor.authorSolis, Nancy
dc.contributor.authorPizarro, Margarita
dc.contributor.authorEscalona, Alex
dc.contributor.authorBoza, Camilo
dc.contributor.authorPerez, Gustavo
dc.contributor.authorDominguez, Angelica
dc.contributor.authorArrese, Marco
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T12:41:12Z
dc.date.available2024-01-10T12:41:12Z
dc.date.issued2010
dc.description.abstractThe enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic disorders associated with obesity. The aim of this study was to evaluate the 11 beta-HSD1 expression in liver, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) in morbidly obese patients undergoing bariatric surgery and its correlations with clinical, anthropometric, and biochemical variables.
dc.description.abstractA prospective study was conducted over a 27-month period. Hepatic, VAT, and SAT samples were obtained at the time of surgery. 11 beta-HSD1 and 18S gene expression was measured using real-time quantitative reverse transcriptase-polymerase chain reaction.
dc.description.abstractForty nine patients met the inclusion criteria [mean age: 42.2 +/- 10 years, body mass index (BMI): 42 +/- 6 kg/m(2), 71% women and 63% with metabolic syndrome (MS)]. 11 beta-HSD1 mRNA levels were higher in liver than fat tissue (p < 0.001), being higher in SAT than in VAT (p < 0.001) without gender-specific differences. Hepatic expression of 11 beta-HSD1 correlated positively with SAT and VAT, alanine aminotransferase (ALT), and serum glucose and was inversely associated with BMI. 11 beta-HSD1 mRNA in VAT correlated positively with insulinemia, ALT, and LDL cholesterol. There were no associations between 11 beta-HSD1 mRNA in SAT and the variables analyzed.
dc.description.abstract11 beta-HSD1 expression is higher in liver in comparison to adipose tissue in obese patients. The observed correlations between hepatic and VAT 11 beta-HSD1 expression with dyslipidemia and insulin resistance suggest that this enzyme might have a pathogenic role in obesity and related metabolic disorders.
dc.description.funderSociedad Chilena de Endocrinologia (SOCHED)
dc.description.funderNational Commission for Scientific and Technological Research of the Chilean Government (CONICYT)
dc.fechaingreso.objetodigital2024-03-14
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11695-009-9937-0
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.pubmedidMEDLINE:19690925
dc.identifier.urihttps://doi.org/10.1007/s11695-009-9937-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77392
dc.identifier.wosidWOS:000273470100012
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.information.autorucMedicina;Baudrand R;S/I;1024
dc.information.autorucMedicina;Boza C;S/I;761
dc.information.autorucMedicina;Carvajal CA;S/I;8586
dc.information.autorucMedicina;Escalona A;S/I;94025
dc.information.autorucMedicina;Fardella CE;S/I;66235
dc.information.autorucMedicina;Pizarro M;S/I;102250
dc.information.autorucMedicina;Pérez G;S/I;5510
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Solís N;S/I;102379
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final83
dc.pagina.inicio77
dc.publisherSPRINGER
dc.revistaOBESITY SURGERY
dc.rightsacceso restringido
dc.subjectObesity
dc.subjectGlucocorticoids
dc.subjectLocal metabolism
dc.subjectAbdominal obesity
dc.subjectAdipose tissue
dc.subject11 beta-hydroxysteroid dehydrogenase
dc.subjectINSULIN-RESISTANCE
dc.subjectNONALCOHOLIC STEATOHEPATITIS
dc.subjectEXPRESSION
dc.subjectGLUCOCORTICOIDS
dc.subjectCARBENOXOLONE
dc.subjectCARBOHYDRATE
dc.subjectMANAGEMENT
dc.subjectCORTISOL
dc.subjectFEATURES
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOverexpression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients
dc.typeartículo
dc.volumen20
sipa.codpersvinculados76095
sipa.codpersvinculados1024
sipa.codpersvinculados761
sipa.codpersvinculados8586
sipa.codpersvinculados94025
sipa.codpersvinculados66235
sipa.codpersvinculados102250
sipa.codpersvinculados5510
sipa.codpersvinculados3538
sipa.codpersvinculados102379
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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