Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150<SUP>Glued</SUP> Deacetylation by Axonal HDAC1

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dc.contributor.authorPathak, Amrita
dc.contributor.authorStanley, Emily M.
dc.contributor.authorHickman, F. Edward
dc.contributor.authorWallace, Natalie
dc.contributor.authorBrewer, Bryson
dc.contributor.authorLi, Deyu
dc.contributor.authorGluska, Shani
dc.contributor.authorPerlson, Eran
dc.contributor.authorFuhrmann, Sabine
dc.contributor.authorAkassoglou, Katerina
dc.contributor.authorBronfman, Francisca
dc.contributor.authorCasaccia, Patrizia
dc.contributor.authorBurnette, Dylan T.
dc.contributor.authorCarter, Bruce D.
dc.date.accessioned2025-01-23T21:22:32Z
dc.date.available2025-01-23T21:22:32Z
dc.date.issued2018
dc.description.abstractDuring development, neurons undergo apoptosis if they do not receive adequate trophic support from tissues they innervate or when detrimental factors activate the p75 neurotrophin receptor (p75NTR) at their axon ends. Trophic factor deprivation (TFD) or activation of p75NTR in distal axons results in a retrograde degenerative signal. However, the nature of this signal and the regulation of its transport are poorly understood. Here, we identify p75NTR intracellular domain (ICD) and histone deacetylase 1 (HDAC1) as part of a retrograde pro-apoptotic signal generated in response to TFD or ligand binding to p75NTR in sympathetic neurons. We report an unconventional function of HDAC1 in retrograde transport of a degenerative signal and its constitutive presence in sympathetic axons. HDAC1 deacetylates dynactin subunit p150(Glued), which enhances its interaction with dynein. These findings define p75NTR ICD as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.devcel.2018.07.001
dc.identifier.eissn1878-1551
dc.identifier.issn1534-5807
dc.identifier.urihttps://doi.org/10.1016/j.devcel.2018.07.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101257
dc.identifier.wosidWOS:000441327300013
dc.issue.numero3
dc.language.isoen
dc.pagina.final+
dc.pagina.inicio376
dc.revistaDevelopmental cell
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRetrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150<SUP>Glued</SUP> Deacetylation by Axonal HDAC1
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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