Association of bilateral oophorectomy and menopause hormone therapy with mild cognitive impairment: the REDLINC X study

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dc.contributor.authorBlumel, J. E.
dc.contributor.authorArteaga, E.
dc.contributor.authorVallejo, M. S.
dc.contributor.authorOjeda, E.
dc.contributor.authorMeza, P.
dc.contributor.authorMartino, M.
dc.contributor.authorRodriguez-Vidal, D.
dc.contributor.authorNanez, M.
dc.contributor.authorTserotas, K.
dc.contributor.authorRojas, J.
dc.contributor.authorRodrigues, M. A.
dc.contributor.authorEspinoza, M. T.
dc.contributor.authorSalinas, C.
dc.contributor.authorParraga-Parraga, J.
dc.contributor.authorChedraui, P.
dc.date.accessioned2025-01-20T22:01:56Z
dc.date.available2025-01-20T22:01:56Z
dc.date.issued2022
dc.description.abstractBackground Dementia is a major public health problem. Estrogen is a regulator of the central nervous system and its deficit could be involved in cognitive decline in older women. Objective This study aimed to evaluate the association of bilateral oophorectomy, menopause hormone therapy (MHT) and other factors on mild cognitive impairment (MCI). Method The case-control study included 941 otherwise healthy postmenopausal women aged 60 years and over from six Latin American countries. Personal and family data were recorded and MCI was assessed using the Montreal Cognitive Assessment test (MoCA). Results Average age, years of education and body mass index were 66.1 +/- 5.8 years, 12.4 +/- 5.0 years and 26.0 +/- 4.3 kg/m(2), respectively. A total of 30.2% had undergone bilateral oophorectomy and 40.3% had used MHT. A total of 232 women (24.7%) had MCI. The prevalence of MCI was higher in women with intact ovaries and non-MHT users as compared to MHT users (29.3% vs. 11.7% [odds ratio (OR) 0.32; 95% confidence interval (CI) 0.20-0.51]). Among oophorectomized women, MCI prevalence was higher among non-MHT users as compared to MHT users (45.2% vs. 12.8% [OR 0.18; 95% CI 0.10-0.32]). Logistic regression analysis determined that the variables associated with MCI were age >65 years (OR 1.69; 95% CI 1.20-2.38), parity (having >2 children; OR 1.69; 95% CI 1.21-2.37), bilateral oophorectomy (OR 1.56; 95% CI 1.09-2.24), hypertension (OR 1.41; 95% CI 1.01-1.96), being sexually active (OR 0.56; 95% CI 0.40-0.79), education >12 years (OR 0.46; 95% CI 0.32-0.65) and MHT use (OR 0.31; 95% CI 0.21-0.46). Conclusion Age, parity, bilateral oophorectomy and hypertension are independent factors associated with MCI; contrary to this, higher educational level, maintaining sexual activity and using MHT are protective factors.
dc.fuente.origenWOS
dc.identifier.doi10.1080/13697137.2021.1951203
dc.identifier.eissn1473-0804
dc.identifier.issn1369-7137
dc.identifier.urihttps://doi.org/10.1080/13697137.2021.1951203
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93909
dc.identifier.wosidWOS:000683586100001
dc.issue.numero2
dc.language.isoen
dc.pagina.final202
dc.pagina.inicio195
dc.revistaClimacteric
dc.rightsacceso restringido
dc.subjectDementias
dc.subjectmild cognitive impairment
dc.subjectMontreal Cognitive Assessment test
dc.subjectpostmenopausal women
dc.subjectbilateral oophorectomy
dc.subjectmenopause hormone therapy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of bilateral oophorectomy and menopause hormone therapy with mild cognitive impairment: the REDLINC X study
dc.typeartículo
dc.volumen25
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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