Improving Amphetamine Therapeutic Selectivity: <i>N,N</i>-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction

dc.contributor.authorSotomayor-Zarate, Ramon
dc.contributor.authorJara, Pablo
dc.contributor.authorAraos, Patricio
dc.contributor.authorVinet, Raul
dc.contributor.authorQuiroz, Gabriel
dc.contributor.authorRenard, Georgina M.
dc.contributor.authorEspinosa, Pedro
dc.contributor.authorHurtado-Guzman, Claudio
dc.contributor.authorMoya, Pablo R.
dc.contributor.authorIturriaga-Vasquez, Patricio
dc.contributor.authorGysling, Katia
dc.contributor.authorReyes-Parada, Miguel
dc.date.accessioned2025-01-23T21:46:36Z
dc.date.available2025-01-23T21:46:36Z
dc.date.issued2014
dc.description.abstractAmphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years, we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,N-dimethyl-thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA, N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a lower potential for producing cardiovascular side effects.
dc.fuente.origenWOS
dc.identifier.doi10.1111/bcpt.12168
dc.identifier.eissn1742-7843
dc.identifier.issn1742-7835
dc.identifier.urihttps://doi.org/10.1111/bcpt.12168
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101728
dc.identifier.wosidWOS:000333969800004
dc.issue.numero5
dc.language.isoen
dc.pagina.final399
dc.pagina.inicio395
dc.revistaBasic & clinical pharmacology & toxicology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImproving Amphetamine Therapeutic Selectivity: <i>N,N</i>-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction
dc.typeartículo
dc.volumen114
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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