Baseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks

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dc.catalogadorgrr
dc.contributor.authorGalgani Fuentes, José
dc.contributor.authorFernández Verdejo, Rodrigo
dc.contributor.authorBray, George A.
dc.contributor.authorSmith, Steven R.
dc.contributor.authorGhosh, Sujoy
dc.contributor.authorJavvadi, Pravalika
dc.contributor.authorRavussin, Eric
dc.date.accessioned2025-04-28T21:46:00Z
dc.date.available2025-04-28T21:46:00Z
dc.date.issued2025
dc.description.abstractBackground & aims: Epidemiological data suggest that participants with lower vs. higher body mass index (BMI) resist exposure to the obesogenic environment. To test this, we analyzed the relationship between overfeeding-induced weight and fat mass gains with baseline BMI and body fat percentage.Methods: In this controlled intervention study, 34 men (age: 26±5 y old; BMI: 25.5±2.4 kg/m2, body fat [DXA]: 19.3±5.1%) consumed for 8 weeks 40% more energy than needed at weight maintenance. The energy costs of weight and fat mass gain were calculated as the 8-week excess energy consumed divided by weight or fat mass gain. Energy expenditure (baseline and after overfeeding) was determined using a metabolic chamber and doubly labeled water. Transcriptomic analysis was conducted from abdominal subcutaneous adipose tissue samples.Results: Body weight increased 7.2±2.1 kg and fat mass 4.0±1.4 kg. There was no statistical association between baseline BMI and weight and fat mass gains. However, baseline body fat percentage was significantly associated with weight (r=0.57) and fat mass (r=0.59) gains. Body fat percentage was also statistically associated with energy cost of weight (r=-0.38) and fat mass (r=-0.40) gains. Metabolic adaptation in energy expenditure (adaptive thermogenesis) was unrelated to the energy cost of weight and fat mass gains. Transcriptomics analysis showed that high energy cost of weight gain was associated with up-regulation of inflammation-related pathways.Conclusion: Body fat percentage at baseline was inversely associated with overfeeding-induced weight and fat gain resistance. The underlying compensatory response appears unrelated to changes in energy expenditure
dc.format.extent29 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1210/clinem/dgaf247
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.pubmedid40254560
dc.identifier.urihttps://doi.org/10.1210/clinem/dgaf247
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103508
dc.information.autorucEscuela de Medicina; Galgani Fuentes, José; 0000-0001-9793-8561; 1011272
dc.information.autorucDepartamento de Ciencias de la Salud; Fernández Verdejo, Rodrigo; 0000-0002-5948-2281; 1071485
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaThe Journal of Clinical Endocrinology & Metabolism
dc.rightsacceso restringido
dc.subjectObesity
dc.subjectAdipose tissue function
dc.subjectAdaptive thermogenesis
dc.subjectFatness
dc.subjectWeight gain
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods02 Zero hunger
dc.subject.ods03 Good health and well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleBaseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks
dc.typeartículo
sipa.codpersvinculados1011272
sipa.codpersvinculados1071485
sipa.trazabilidadORCID;2025-04-21
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