Innovative multiple nanoemulsion (W/O/W) based on Chilean honeybee pollen improves their permeability, antioxidant and antibacterial activity

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dc.contributor.authorValdivia-Olivares, R. Y.
dc.contributor.authorMartinez-Gonzalez, E. A.
dc.contributor.authorMontenegro, G.
dc.contributor.authorBridi, R.
dc.contributor.authorAlvarez-Figueroa, M. J.
dc.contributor.authorGonzalez-Aramundiz, J. V.
dc.date.accessioned2025-01-20T20:14:33Z
dc.date.available2025-01-20T20:14:33Z
dc.date.issued2023
dc.description.abstractBeehive derivatives, including honeybee pollen (HBP), have been extensively studied for their beneficial health properties and potential therapeutic use. Its high polyphenol content gives it excellent antioxidant and antibacterial properties. Today its use is limited due to poor organoleptic properties, low solubility, stability, and permeability under physiological conditions. A novel edible multiple W/O/W nanoemulsion (BP-MNE) to encapsulate the HBP extract was designed and optimized to overcome these limitations. The new BP-MNE has a small size (-100 nm), a zeta potential greater than +30 mV, and efficiently encapsulated phenolic compounds (-82%). BP-MNE stability was measured under simulated physiological conditions and storage conditions (4 months); in both cases, stability was promoted. The formulation's antioxidant and antibacterial (Streptococcus pyogenes) activity was analyzed, obtaining a higher effect than the non-encapsulated compounds in both cases. In vitro permeability was tested, observing a high permeability of the phenolic compounds when they are nanoencapsulated. With these results, we propose our BP-MNE as an innovative solution to encapsulate complex matrices, such as HBP extract, as a platform to develop functional foods.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.foodres.2023.112767
dc.identifier.eissn1873-7145
dc.identifier.issn0963-9969
dc.identifier.urihttps://doi.org/10.1016/j.foodres.2023.112767
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92204
dc.identifier.wosidWOS:000984098500001
dc.language.isoen
dc.revistaFood research international
dc.rightsacceso restringido
dc.subjectFunctional foods
dc.subjectHoneybee pollen
dc.subjectPolyphenols
dc.subjectComplex matrix nanoencapsulation
dc.subjectW/O/W nanoemulsions
dc.subjectMultiple nanoemulsion
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInnovative multiple nanoemulsion (W/O/W) based on Chilean honeybee pollen improves their permeability, antioxidant and antibacterial activity
dc.typeartículo
dc.volumen168
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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