Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer

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dc.contributor.authorGoni, Francisca J.
dc.contributor.authorPena-Oyarzun, Daniel
dc.contributor.authorTorres, Vicente A.
dc.contributor.authorReyes, Montserrat
dc.date.accessioned2025-01-20T22:05:25Z
dc.date.available2025-01-20T22:05:25Z
dc.date.issued2021
dc.description.abstractBackground: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, which, according to histopathological criteria, are referred to as oral dysplasia and their diagnosis are associated with higher rates of malignant transformation towards cancer. We recently reported that aberrant activation of the Wnt/beta catenin pathway is due to overexpression of Wnt ligands in oral dysplasia. However, the expression of other regulators of this pathway, namely components of the beta-catenin destruction complex has not been explored in oral dysplasia.
dc.description.abstractMaterial and Methods: Using immunohistochemical analyses, we evaluated nuclear expression of beta catenin and its association with Wnt3a and Wnt5a. Likewise, components of the beta-catenin destruction complex, including Adenomatous Polyposis Coli (APC), Axin and Glycogen Synthase Kinase 3 beta (GSK-3 beta) were also evaluated in oral dysplasia and OSCC biopsies
dc.description.abstractResults: We found that moderate and severe dysplasia samples, which harbored increased expression of nuclear beta catenin, depicted augmented cytoplasmic expression of GSK 3 beta, Axin and APC, in comparison with OSCC samples. Also, GSK-3 beta was found nuclear in mild dysplasia and OSCC samples, when compared with other study samples.
dc.description.abstractConclusions: Cytoplasmic levels of components of the beta-catenin destruction complex are increased in oral dysplasia and might be responsible of augmented nuclear beta catenin.
dc.fuente.origenWOS
dc.identifier.doi10.4317/medoral.24528
dc.identifier.issn1698-6946
dc.identifier.urihttps://doi.org/10.4317/medoral.24528
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94143
dc.identifier.wosidWOS:000715857900006
dc.issue.numero6
dc.language.isoen
dc.pagina.finalE737
dc.pagina.inicioE729
dc.revistaMedicina oral patologia oral y cirugia bucal
dc.rightsacceso restringido
dc.subjectOral cancer
dc.subjectoral dysplasia
dc.subjectbeta-Catenin
dc.subjectWnt ligands
dc.subjectdestruction complex
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExpression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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