Consensus Statement on the definition and classification of metabolic hyperferritinaemia

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dc.contributor.authorValenti, Luca
dc.contributor.authorCorradini, Elena
dc.contributor.authorAdams, Leon A.
dc.contributor.authorAigner, Elmar
dc.contributor.authorAlqahtani, Saleh
dc.contributor.authorArrese, Marco
dc.contributor.authorBardou-Jacquet, Edouard
dc.contributor.authorBugianesi, Elisabetta
dc.contributor.authorFernandez-Real, Jose-Manuel
dc.contributor.authorGirelli, Domenico
dc.contributor.authorHagstrom, Hannes
dc.contributor.authorHenninger, Benjamin
dc.contributor.authorKowdley, Kris
dc.contributor.authorLigabue, Guido
dc.contributor.authorMcClain, Donald
dc.contributor.authorLaine, Fabrice
dc.contributor.authorMiyanishi, Koji
dc.contributor.authorMuckenthaler, Martina U.
dc.contributor.authorPagani, Alessia
dc.contributor.authorPedrotti, Patrizia
dc.contributor.authorPietrangelo, Antonello
dc.contributor.authorPrati, Daniele
dc.contributor.authorRyan, John D.
dc.contributor.authorSilvestri, Laura
dc.contributor.authorSpearman, C. Wendy
dc.contributor.authorStal, Per
dc.contributor.authorTsochatzis, Emmanuel A.
dc.contributor.authorVinchi, Francesca
dc.contributor.authorZheng, Ming-Hua
dc.contributor.authorZoller, Heinz
dc.date.accessioned2025-01-20T20:17:01Z
dc.date.available2025-01-20T20:17:01Z
dc.date.issued2023
dc.description.abstractHyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron accumulation in the body and is associated with an increased risk of cardiometabolic and liver diseases. Genetic variants that modulate iron homeostasis and tissue levels of iron are the main determinants of serum levels of ferritin in individuals with metabolic dysfunction, raising the hypothesis that iron accumulation might be implicated in the pathogenesis of insulin resistance and the related organ damage. However, validated criteria for the non-invasive diagnosis of metabolic hyperferritinaemia and the staging of iron overload are still lacking, and there is no clear evidence of a benefit for iron depletion therapy. Here, we provide an overview of the literature on the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction, and on the associated clinical outcomes. We propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, which has been agreed on by a multidisciplinary global panel of expert researchers. The goal is to foster studies into the epidemiology, genetics, pathophysiology, clinical relevance and treatment of metabolic hyperferritinaemia, for which we provide suggestions on the main unmet needs, optimal design and clinically relevant outcomes.
dc.description.abstractThis Consensus Statement discusses the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction. The authors propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, highlight research gaps and provide suggestions for the design and outcome measures for future studies.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41574-023-00807-6
dc.identifier.eissn1759-5037
dc.identifier.issn1759-5029
dc.identifier.urihttps://doi.org/10.1038/s41574-023-00807-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92369
dc.identifier.wosidWOS:000940649200001
dc.issue.numero5
dc.language.isoen
dc.pagina.final310
dc.pagina.inicio299
dc.revistaNature reviews endocrinology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleConsensus Statement on the definition and classification of metabolic hyperferritinaemia
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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