Mucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study

Simple item page
dc.contributor.authorGonzalez, Agustin
dc.contributor.authorLatorre, Gonzalo
dc.contributor.authorParedes, Loreto
dc.contributor.authorMontoya, Lorena
dc.contributor.authorMaquilon, Sara
dc.contributor.authorShah, Shailja C.
dc.contributor.authorEspino, Alberto
dc.contributor.authorSabatini, Natalia
dc.contributor.authorTorres, Javiera
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorKolbach, Marianne
dc.date.accessioned2025-01-20T22:02:39Z
dc.date.available2025-01-20T22:02:39Z
dc.date.issued2021
dc.description.abstractINTRODUCTION: Autoimmune gastritis (AIG) is associated with nutritional deficiencies, autoimmune diseases, and gastric malignancies. The aims of the study were to test the hypothesis that mucocutaneous (MC) manifestations occur more often in patients with vs without AIG and to delineate patterns of MC manifestations in AIG.
dc.description.abstractMETHODS: A single-center, prospective 2:1 case-control study was conducted. Cases were patients with the diagnosis of AIG based on consistent serologic and histologic findings. Controls had a normal gastric biopsy. MC manifestations were independently evaluated by 3 experienced dermatologists. We conducted a multivariable logistic regression model adjusted for age, sex, Helicobacter pylori, tobacco use, and alcohol consumption to estimate the association between AIG (vs no AIG) and MC manifestations (adjusted odds ratio; 95% confidence interval).
dc.description.abstractRESULTS: Weprospectively enrolled 60 cases and 30 controls (mean age 53.5 +/- 15.8 vs 53.4 +/- 14.5 years; 75% vs 73.3% women). The pooled prevalence ofMCimmune-mediated diseases was higher in patients with vs without AIG (66.7% vs 23.3%; adjusted odds ratio 12.01 [95% confidence interval: 3.51-41.13]). In patients with AIG, seropositive vs seronegative anti-intrinsic factor antibodies more often had concomitant immunological diseases with MC manifestations (100% vs 58.5%; P=0.016). The most common MC immune-mediated diseases in AIG were Sjogren syndrome (n=5, 8.3%), alopecia areata (n = 5, 8.3%), and vitiligo (n = 4, 6.7%). Nutritional deficiency-related MC findings, mainly xerosis, lingual, and nail disorders, were also more common in AIG.
dc.description.abstractDISCUSSION: This is the first comparative study specifically designed to evaluate MC manifestations in AIG. We demonstrated that AIG ismore frequently associated with both immune- and nutritional deficiencyrelatedMCmanifestations, whichmight have both diagnostic and therapeutic clinical implications.
dc.fuente.origenWOS
dc.identifier.doi10.14309/ajg.0000000000001501
dc.identifier.eissn1572-0241
dc.identifier.issn0002-9270
dc.identifier.urihttps://doi.org/10.14309/ajg.0000000000001501
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93997
dc.identifier.wosidWOS:000752538300015
dc.issue.numero12
dc.language.isoen
dc.pagina.final2384
dc.pagina.inicio2374
dc.revistaAmerican journal of gastroenterology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study
dc.typeartículo
dc.volumen116
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas