Extracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study

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dc.article.number332
dc.catalogadoraba
dc.contributor.authorAit Hssain, Ali
dc.contributor.authorPetit, Matthieu
dc.contributor.authorWiest, Clemens
dc.contributor.authorSimon, Laura
dc.contributor.authorAl-Fares, Abdulrahman A.
dc.contributor.authorHany, Ahmed
dc.contributor.authorGarcia-Gomez, Dafna I.
dc.contributor.authorBesa, Santiago
dc.contributor.authorNseir, Saad
dc.contributor.authorGuervilly, Christophe
dc.contributor.authorAlqassem, Wael
dc.contributor.authorLesouhaitier, Mathieu
dc.contributor.authorChelaru, Adrian
dc.contributor.authorSin, Simon W.
dc.contributor.authorRoncon-Albuquerque, Roberto
dc.contributor.authorGiani, Marco
dc.contributor.authorLepper, Philipp M.
dc.contributor.authorLavillegrand, Jean-Rémi
dc.contributor.authorPark, Sunghoon
dc.contributor.authorSchellongowski, Peter
dc.contributor.authorFawzy Hassan, Ibrahim
dc.contributor.authorCombes, Alain
dc.contributor.authorSonneville, Romain
dc.contributor.authorSchmidt, Matthieu
dc.contributor.authorSalas Villarroel, Patricio
dc.contributor.authorBravo Morales, Sebastián
dc.date.accessioned2024-10-14T20:00:57Z
dc.date.available2024-10-14T20:00:57Z
dc.date.issued2024
dc.date.updated2024-10-13T00:02:46Z
dc.description.abstractAbstract Objective To report the outcomes of patients with severe tuberculosis (TB)-related acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO), including predictors of 90-day mortality and associated complications. Methods An international multicenter retrospective study was conducted in 20 ECMO centers across 13 countries between 2002 and 2022. Results We collected demographic data, clinical details, ECMO-related complications, and 90-day survival status for 79 patients (median APACHE II score of 20 [25th to 75th percentile, 16 to 28], median age 39 [28 to 48] years, PaO2/FiO2 ratio of 69 [55 to 82] mmHg before ECMO) who met the inclusion criteria. Thoracic computed tomography showed that 61 patients (77%) had cavitary TB, while 18 patients (23%) had miliary TB. ECMO-related complications included major bleeding (23%), ventilator-associated pneumonia (41%), and bloodstream infections (32%). The overall 90-day survival rate was 51%, with a median ECMO duration of 20 days [10 to 34] and a median ICU stay of 42 days [24 to 65]. Among patients on VV ECMO, those with miliary TB had a higher 90-day survival rate than those with cavitary TB (90-day survival rates of 81% vs. 46%, respectively; log-rank P = 0.02). Multivariable analyses identified older age, drug-resistant TB, and pre-ECMO SOFA scores as independent predictors of 90-day mortality. Conclusion The use of ECMO for TB-related ARDS appears to be justifiable. Patients with miliary TB have a much better prognosis compared to those with cavitary TB on VV ECMO.
dc.fechaingreso.objetodigital2024-10-13
dc.fuente.origenBiomed Central
dc.identifier.doi10.1186/s13054-024-05110-y
dc.identifier.issn1364-8535
dc.identifier.urihttps://doi.org/10.1186/s13054-024-05110-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88210
dc.identifier.wosidWOS:001337655300001
dc.information.autorucEscuela de Medicina; Salas Villarroel, Patricio; S/I; 11903
dc.information.autorucEscuela de Medicina; Bravo Morales, Sebastián; 0000-0003-0998-8433; 13431
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaCritical Care
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectExtracorporeal membrane oxygenation
dc.subjectAcute respiratory distress syndrome
dc.subjectTuberculosis
dc.subjectMiliary
dc.subjectOutcome
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study
dc.typeartículo
dc.volumen28
sipa.codpersvinculados11903
sipa.codpersvinculados13431
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