Epileptiform activity during rewarming from moderate cerebral hypothermia in the near-term fetal sheep

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dc.contributor.authorGerrits, LC
dc.contributor.authorBattin, MR
dc.contributor.authorBennet, L
dc.contributor.authorGonzalez, H
dc.contributor.authorGunn, AJ
dc.date.accessioned2025-01-21T01:07:08Z
dc.date.available2025-01-21T01:07:08Z
dc.date.issued2005
dc.description.abstractModerate hypothermia is consistently neuroprotective after hypoxic-ischemic insults and is the subject of ongoing clinical trials. In pilot studies, we observed rebound seizure activity in one infant during rewarming from a 72-h period of hypothermia. We therefore quantified the development of EEG-defined seizures during rewarming in an experimental paradigm of delayed cooling for cerebral ischemia. Moderate cerebral hypothermia (n = 9) or sham cooling (n = 13) was initiated 5.5 It after reperfusion from a 30-min period of bilateral carotid occlusion in near-term fetal sheep and continued for 72 h after the insult. During spontaneous rewarming, fetal extradural temperature rose from 32.5 +/- 0.6degreesC to control levels (39.4 +/- 0.1degreesC) in 47 +/- 6 min. Carotid blood flow and mean arterial blood pressure increased transiently during rewarming. The cooling group showed a significant increase in electrical seizure events 2, 3, and 5 h after rewarming, maximal at 2 h (2.9 +/- 1.2 versus 0.5 +/- 0.5 events/h; p < 0.05). From 6 h after rewarming, there was significant difference between the groups. Individual seizures were typically short (28.8 +/- 5.8 s versus 29.0 +/- 6.8 s in sham cooled; NS), and of modest amplitude (35.9 +/- 2.8 versus 38.8 +/- 3.4 muV; NS). Neuronal loss in the parasagittal cortex was significantly reduced in the cooled group (51 +/- 9% versus 91 +/- 5%; p < 0.002) and was not correlated with rebound epileptiform activity. In conclusion, rapid rewarming after a prolonged interval of therapeutic hypothermia can be associated with a transient increase in epileptiform events but does not seem to have significant adverse implications for neural outcome.
dc.description.funderNICHD NIH HHS
dc.fuente.origenWOS
dc.identifier.doi10.1203/01.PDR.0000150801.61188.5F
dc.identifier.eissn1530-0447
dc.identifier.issn0031-3998
dc.identifier.urihttps://doi.org/10.1203/01.PDR.0000150801.61188.5F
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96282
dc.identifier.wosidWOS:000227152100006
dc.issue.numero3
dc.language.isoen
dc.pagina.final346
dc.pagina.inicio342
dc.revistaPediatric research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEpileptiform activity during rewarming from moderate cerebral hypothermia in the near-term fetal sheep
dc.typeartículo
dc.volumen57
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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