Plasma Neurofilament Light as a Biomarker of Neurological Involvement in Wilson's Disease

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dc.contributor.authorShribman, Samuel
dc.contributor.authorHeller, Carolin
dc.contributor.authorBurrows, Maggie
dc.contributor.authorHeslegrave, Amanda
dc.contributor.authorSwift, Imogen
dc.contributor.authorFoiani, Martha S.
dc.contributor.authorGillett, Godfrey T.
dc.contributor.authorTsochatzis, Emmanuel A.
dc.contributor.authorRowe, James B.
dc.contributor.authorGerhard, Alex
dc.contributor.authorButler, Chris R.
dc.contributor.authorMasellis, Mario
dc.contributor.authorBremner, Fion
dc.contributor.authorMartin, Alison
dc.contributor.authorJung, Lynne
dc.contributor.authorCook, Paul
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorBandmann, Oliver
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorWarner, Thomas T.
dc.date.accessioned2025-01-20T23:56:06Z
dc.date.available2025-01-20T23:56:06Z
dc.date.issued2021
dc.description.abstractBackground Outcomes are unpredictable for neurological presentations of Wilson's disease (WD). Dosing regimens for chelation therapy vary and monitoring depends on copper indices, which do not reflect end-organ damage. Objective To identify a biomarker for neurological involvement in WD. Methods Neuronal and glial-specific proteins were measured in plasma samples from 40 patients and 38 age-matched controls. Patients were divided into neurological or hepatic presentations and those with recent neurological presentations or deterioration associated with non-adherence were subcategorized as having active neurological disease. Unified WD Rating Scale scores and copper indices were recorded. Results Unlike copper indices, neurofilament light (NfL) concentrations were higher in neurological than hepatic presentations. They were also higher in those with active neurological disease when controlling for severity and correlated with neurological examination subscores in stable patients. Conclusion NfL is a biomarker of neurological involvement with potential use in guiding chelation therapy and clinical trials for novel treatments. (c) 2020 University College London.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
dc.fuente.origenWOS
dc.identifier.doi10.1002/mds.28333
dc.identifier.eissn1531-8257
dc.identifier.issn0885-3185
dc.identifier.urihttps://doi.org/10.1002/mds.28333
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95132
dc.identifier.wosidWOS:000579457300001
dc.issue.numero2
dc.language.isoen
dc.pagina.final508
dc.pagina.inicio503
dc.revistaMovement disorders
dc.rightsacceso restringido
dc.subjectWilson's disease
dc.subjectbiomarkers
dc.subjectneurofilament light
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlasma Neurofilament Light as a Biomarker of Neurological Involvement in Wilson's Disease
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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