WebRASP: a server for computing energy scores to assess the accuracy and stability of RNA 3D structures

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dc.catalogadoraba
dc.contributor.authorNorambuena, T.
dc.contributor.authorCares, J. F.
dc.contributor.authorCapriotti, E.
dc.contributor.authorMelo Ledermann, Francisco Javier
dc.date.accessioned2025-02-06T19:14:23Z
dc.date.available2025-02-06T19:14:23Z
dc.date.issued2013
dc.description.abstractSummary: The understanding of the biological role of RNA molecules has changed. Although it is widely accepted that RNAs play important regulatory roles without necessarily coding for proteins, the functions of many of these non-coding RNAs are unknown. Thus, determining or modeling the 3D structure of RNA molecules as well as assessing their accuracy and stability has become of great importance for characterizing their functional activity. Here, we introduce a new web application, WebRASP, that uses knowledge-based potentials for scoring RNA structures based on distance-dependent pairwise atomic interactions. This web server allows the users to upload a structure in PDB format, select several options to visualize the structure and calculate the energy profile. The server contains online help, tutorials and links to other related resources. We believe this server will be a useful tool for predicting and assessing the quality of RNA 3D structures. Availability and implementation: The web server is available at http://melolab.org/webrasp. It has been tested on the most popular web browsers and requires Java plugin for Jmol visualization.
dc.format.extent2 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1093/bioinformatics/btt441
dc.identifier.eissn1367-4811
dc.identifier.issn1367-4803
dc.identifier.pubmedid23929030
dc.identifier.pubmedidPMC3789544
dc.identifier.scopusid2-s2.0-84885604465
dc.identifier.urihttps://doi.org/10.1093/bioinformatics/btt441
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102176
dc.identifier.wosidWOS:000325485800021
dc.information.autorucFacultad de Ciencias Biológicas; Melo Ledermann, Francisco Javier; 0000-0002-0424-5991; 82342
dc.issue.numero20
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final2650
dc.pagina.inicio2649
dc.revistaBioinformatics (Oxford, England)
dc.rightsacceso abierto
dc.rights.licenseAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc570
dc.subject.deweyBiología
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWebRASP: a server for computing energy scores to assess the accuracy and stability of RNA 3D structures
dc.typeartículo
dc.volumen29
sipa.codpersvinculados82342
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