A spatial transcriptomic signature of 26 genes resolved at single-cell resolution characterizes high-risk gastric cancer precursors

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dc.article.number52
dc.catalogadorpva
dc.contributor.authorHuang, Robert J.
dc.contributor.authorWichmann Pérez, Ignacio Alberto
dc.contributor.authorSu, Andrew
dc.contributor.authorSathe, Anuja
dc.contributor.authorShum, Miranda V.
dc.contributor.authorGrimes, Susan M.
dc.contributor.authorMeka, Rithika
dc.contributor.authorAlmeda, Alison
dc.contributor.authorBai, Xiangqi
dc.contributor.authorShen, Jeanne
dc.contributor.authorNguyen, Quan
dc.contributor.authorLuo, Ingrid
dc.contributor.authorHan, Summer S.
dc.contributor.authorAmieva, Manuel R.
dc.contributor.authorHa Hwang, Joo
dc.contributor.authorJi, Hanlee P.
dc.date.accessioned2025-04-11T17:09:05Z
dc.date.available2025-04-11T17:09:05Z
dc.date.issued2025
dc.description.abstractGastric cancer precursors demonstrate highly-variable rates of progression toward neoplasia. Certain high-risk precursors, such as gastric intestinal metaplasia with advanced histologic features, may be at up to 30-fold increased risk for progression compared to lower-risk intestinal metaplasia. The biological differences between high- and low-risk lesions have been incompletely explored. In this study, we use several clinical cohorts to characterize the microenvironment of advanced gastric cancer precursors relative to low-risk lesions using bulk, spatial, and single-cell gene expression assays. We identified a 26-gene panel which is associated with advanced lesions, localizes to metaplastic glands on histopathology, and is expressed in aberrant mature and immature intestinal cells not normally present in the healthy stomach. This gene expression signature suggests an important role of the immature intestinal lineages in promoting carcinogenesis in the metaplastic microenvironment. These findings may help to inform future biomarker development and strategies of gastric cancer prevention.
dc.fechaingreso.objetodigital2025-04-11
dc.format.extent13 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41698-025-00816-w
dc.identifier.eissn2397-768X
dc.identifier.urihttps://doi.org/10.1038/s41698-025-00816-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103216
dc.information.autorucEscuela de Medicina; Wichmann Pérez, Ignacio Alberto; 0000-0002-1115-2937; 149908
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherSpringer Nature
dc.revistanpj Precision Oncology
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGastric cancer
dc.subjectPredictive markers
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA spatial transcriptomic signature of 26 genes resolved at single-cell resolution characterizes high-risk gastric cancer precursors
dc.typeartículo
dc.volumen9
sipa.codpersvinculados149908
sipa.trazabilidadORCID;2025-03-03
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