Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

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dc.catalogadordfo
dc.contributor.authorGomez-Lopez, Nardhy
dc.contributor.authorRomero, Roberto
dc.contributor.authorEscobar, Maria
dc.contributor.authorCarvajal, Javier
dc.contributor.authorEchavarria, Maria
dc.contributor.authorAlbornoz, Ludwig
dc.contributor.authorNasner, Daniela
dc.contributor.authorMiller, Derek
dc.contributor.authorGallo, Dahiana
dc.contributor.authorGalaz Alarcón, José Carlo
dc.contributor.authorArenas-Hernandez, Marcia
dc.contributor.authorBhatti, Gaurav
dc.contributor.authorDone, Bogdan
dc.contributor.authorZambrano, Maria
dc.contributor.authorRamos, Isabella
dc.contributor.authorFernandez, Paula
dc.contributor.authorPosada, Leandro
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorJung, Eunjung
dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorSuksai, Manaphat
dc.contributor.authorGotsch, Francesca
dc.contributor.authorBosco, Mariachiara
dc.contributor.authorThan, Nandor
dc.contributor.authorTarca, Adi
dc.date.accessioned2025-04-15T19:06:33Z
dc.date.available2025-04-15T19:06:33Z
dc.date.issued2022
dc.descriptionPregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we profiled the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and showed alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 showed enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-pregnant individuals display a stronger response to repel infection. Furthermore, the plasma proteome can accurately identify COVID-19 patients, even when asymptomatic or with mild symptoms. This study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients.
dc.fuente.origenORCID
dc.identifier.doi10.21203/rs.3.rs-1906806/v1
dc.identifier.urihttps://doi.org/10.21203/rs.3.rs-1906806/v1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103309
dc.information.autorucEscuela de Medicina; Galaz Alarcon Jose Carlo; S/I; 1034327
dc.language.isoes
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
dc.typepreprint
sipa.codpersvinculados1034327
sipa.trazabilidadORCID;2025-04-14
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