LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV

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dc.contributor.authorIgnacio Vargas, Jose
dc.contributor.authorRivera, Katherine
dc.contributor.authorArrese, Marco
dc.contributor.authorBenitez, Carlos
dc.contributor.authorBarrera, Francisco
dc.contributor.authorHugo, Monrroy
dc.contributor.authorPablo Arab, Juan
dc.contributor.authorPino, Karla
dc.contributor.authorBarrera, Aldo
dc.contributor.authorLopez-Lastra, Marcelo
dc.contributor.authorRigotti, Attilio
dc.contributor.authorSoza, Alejandro
dc.date.accessioned2025-01-20T22:01:37Z
dc.date.available2025-01-20T22:01:37Z
dc.date.issued2022
dc.description.abstractHCV infection is associated with an increased incidence of cardiovascular (CV) events. Mechanisms underlying this association remain unknown. In our study, twenty HCV patients (median age 60.5 years, 65% male and 80% with cirrhosis) were evaluated prior, during and after direct-acting antiviral treatment. Ninety percent of patients achieved sustained virological response (SVR). Significant changes were observed in LDL particle size index, measured by LDL-C/apoB ratio, which increased after treatment (p = 0.023). In addition, HDL antioxidant capacity improved gradually from 34.4% at baseline to 42.4% at 4 weeks (p = 0.011), 65.9% at end of treatment EOT (p = 0.002) and remained elevated at 12-week (p = 0.001) after EOT compared to baseline values. Our findings suggest that a shift to a less atherogenic lipid profile may be a possible mechanism associated with CV risk reduction in patients with HCV infection achieving SVR. (c) 2021 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.description.funderFONDECYT from CONICYT, Chile
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.aohep.2021.100555
dc.identifier.issn1665-2681
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2021.100555
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93860
dc.identifier.wosidWOS:000711967500003
dc.issue.numero1
dc.language.isoen
dc.revistaAnnals of hepatology
dc.rightsacceso restringido
dc.subjectHepatitis C virus
dc.subjectDirect-acting antivirals
dc.subjectSustained virological response
dc.subjectCardiovascular risk
dc.subjectLDL particle size
dc.subjectHDL functionality
dc.subjectHDL antioxidant capacity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV
dc.typeartículo
dc.volumen27
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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