Impact of Gut and Metabolic Hormones on Feeding Reward

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dc.contributor.authorKlockars, Anica
dc.contributor.authorLevine, Allen S.
dc.contributor.authorHead, Mitchell A.
dc.contributor.authorPerez-Leighton, Claudio E.
dc.contributor.authorKotz, Catherine M.
dc.contributor.authorOlszewski, Pawel K.
dc.date.accessioned2025-01-20T23:52:06Z
dc.date.available2025-01-20T23:52:06Z
dc.date.issued2021
dc.description.abstractIngestion of food activates a cascade of endocrine responses (thereby reflecting a contemporaneous feeding status) that include the release of hormones from the gastrointestinal (GI) tract, such as cholecystokinin (CCK), glucagonlike peptide YY (PYY), peptide PP, and oleoylethanolamide, as well as suppression of ghrelin secretion. The pancreas and adipose tissue, on the other hand, release hormones that serve as a measure of the current metabolic state or the long-term energy stores, that is, insulin, leptin, and adiponectin. It is well known and intuitively understandable that these hormones target either directly (by crossing the blood-brain barrier) or indirectly (e.g., via vagal input) the "homeostatic" brainstem-hypothalamic pathways involved in the regulation of appetite. The current article focuses on yet another target of the metabolic and GI hormones that is critical in inducing changes in food intake, namely, the reward system. We discuss the physiological basis of this functional interaction, its importance in the control of appetite, and the impact that disruption of this crosstalk has on energy intake in select physiological and pathophysiological states. We conclude that metabolic and GI hormones have a capacity to strengthen or weaken a response of the reward system to a given food, and thus, they are fundamental in ensuring that feeding reward is plastic and dependent on the energy status of the organism. (C) 2021 American Physiological Society.
dc.fuente.origenWOS
dc.identifier.doi10.1002/cphy.c190042
dc.identifier.issn2040-4603
dc.identifier.urihttps://doi.org/10.1002/cphy.c190042
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94886
dc.identifier.wosidWOS:000618794800002
dc.issue.numero2
dc.language.isoen
dc.pagina.final1447
dc.pagina.inicio1425
dc.revistaComprehensive physiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleImpact of Gut and Metabolic Hormones on Feeding Reward
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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