Dendritic morphology and orientation of pyramidal cells of the neocortex in two groups of early postnatal undernourished-rehabilitated rats

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dc.contributor.authorCordero, ME
dc.contributor.authorValenzuela, CY
dc.contributor.authorRodriguez, A
dc.contributor.authorAboitiz, F
dc.date.accessioned2025-01-21T01:09:31Z
dc.date.available2025-01-21T01:09:31Z
dc.date.issued2003
dc.description.abstractPostnatal undernutrition in animals and in humans leads to significant reduction in basal dendritic arborization of layer Vth pyramidal cells of the neocortex. Under the hypothesis that there are critical developmental periods for undernutrition to produce alterations in dendritic differentiation, we studied apical dendritic morphology and orientation of pyramidal cells from the deeper layers of the neocortex in rats undernourished until day 10 (UP10), until weaning (UP21) and in a control group (Q. Neurons were stained by the Golgi-Cox method. The main findings are: (i) an increased number of atypically oriented pyramids with apical dendrites extremely short in (UP10) and (UP21) groups and, (ii) the presence of classical pyramids with significantly longer apical dendrites in layers V and VI in (UP10) and (UP21) groups than in the control group (Q. We believe that undernutrition may disturb critically the early postnatal brain development by altering intrinsic factors and extracellular molecular signals that guide and regulate the apical dendritic growth of neocortex large pyramidal cells. (C) 2003 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0165-3806(03)00013-0
dc.identifier.issn0165-3806
dc.identifier.urihttps://doi.org/10.1016/S0165-3806(03)00013-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96592
dc.identifier.wosidWOS:000182571100005
dc.issue.numero1
dc.language.isoen
dc.pagina.final45
dc.pagina.inicio37
dc.revistaDevelopmental brain research
dc.rightsacceso restringido
dc.subjectatypically oriented pyramid
dc.subjectneocortex
dc.subjectundernutrition
dc.subjectrehabilitation
dc.subject.ods02 Zero Hunger
dc.subject.odspa02 Hambre cero
dc.titleDendritic morphology and orientation of pyramidal cells of the neocortex in two groups of early postnatal undernourished-rehabilitated rats
dc.typeartículo
dc.volumen142
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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