Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro

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dc.article.numbere00798
dc.contributor.authorHenriquez A.
dc.contributor.authorVargas J.P.
dc.contributor.authorLandahur C.
dc.contributor.authorCorrales N.
dc.contributor.authorAgurto-Munoz A.
dc.contributor.authorGonzalez P.A.
dc.contributor.authorAgurto-Munoz C.
dc.date.accessioned2025-05-01T10:31:15Z
dc.date.available2025-05-01T10:31:15Z
dc.date.issued2023
dc.description.abstract© 2023Herpes simplex virus type 2 (HSV-2) is a human infectious agent with significant impact on public health due to its high prevalence in the population and its ability to elicit a wide range of diseases, from mild to severe. Although several antiviral drugs, such as acyclovir, are currently available to treat HSV-2-related clinical manifestations, their effectiveness is poor. Therefore, the identification and development of new antiviral drugs against HSV-2 is necessary. Seaweeds are attractive candidates for such purposes because they are a vast source of natural products due to their highly diverse compounds, many with demonstrated biological activity. In this study, we evaluated the in vitro antiviral potential of red algae extracts obtained from Agarophyton chilense, Mazzaella laminarioides, Porphyridium cruentum, and Porphyridium purpureum against HSV-2. The phycocolloids agar and carrageenan obtained from the macroalgae dry biomass of A. chilense and M. laminarioides and the exopolysaccharides from P. cruentum and P. purpureum were evaluated. The cytotoxicity of these extracts and the surpluses obtained in the extraction process of the agar and carrageenans were evaluated in human epithelial cells (HeLa cells) in addition to their antiviral activity against HSV-2, which were used to calculate selectivity indexes (SIs). Several compounds displayed antiviral activity against HSV-2, but carrageenans were not considered as a potential antiviral therapeutic agent when compared to the other algae extracts with a SI of 23.3. Future assays in vivo models for HSV-2 infection should reveal the therapeutic potential of these algae compounds as new antivirals against this virus.
dc.description.funderDepartamento de Genética Molecular y Microbiología
dc.description.funderDepartment of Endocrinology
dc.description.funderDesarrollo Científico y Tecnológico
dc.description.funderFONDEQUIP
dc.description.funderFacultad de Ciencias Biológicas
dc.description.funderFacultad de Medicina
dc.description.funderRegional Government of Antofagasta
dc.description.funderResearch and Development National Agency of Chile
dc.description.funderFONDECYT
dc.description.funderFONDEF
dc.description.funderPontificia Universidad Católica de Chile
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.format.extent13 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.btre.2023.e00798
dc.identifier.eisbn978-1-5106-5352-8
dc.identifier.eissn1542-7714
dc.identifier.isbn978-1-5106-5351-1
dc.identifier.issn2215017X
dc.identifier.pubmedid40243597
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85153797661
dc.identifier.urihttps://doi.org/10.1016/j.btre.2023.e00798
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103732
dc.identifier.wosidWOS:001119129400023
dc.information.autorucFacultad de Ciencias Biológicas; Gonzalez Munoz Pablo Alberto; 0000-0001-7709-6870; 15616
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final159
dc.pagina.inicio153
dc.relation.ispartofInternational Conference on Intelligent User Interfaces (30a. : 2025)
dc.revistaBiotechnology Reports
dc.rightsacceso abierto
dc.subjectAgarophyton chilense
dc.subjectAntiviral activity
dc.subjectHerpes simplex type 2
dc.subjectMazzaella laminarioides
dc.subjectPorphyridium cruentum
dc.subjectPorphyridium purpureum
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAntiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
dc.typeartículo
dc.volumen38
sipa.codpersvinculados15616
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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