REGULATION OF [H-3] NOREPINEPHRINE RELEASE BY N-METHYL-D-ASPARTATE RECEPTORS IN MINISLICES FROM THE DENTATE GYRUS AND THE CA(1)-CA(3) AREA OF THE RAT HIPPOCAMPUS

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dc.contributor.authorANDRES, ME
dc.contributor.authorBUSTOS, G
dc.contributor.authorGYSLING, K
dc.date.accessioned2025-01-23T19:21:31Z
dc.date.available2025-01-23T19:21:31Z
dc.date.issued1993
dc.description.abstractIt has been reported previously that N-methyl-D-aspartic acid induces a significant release of [H-3] norepinephrine preaccumulated in slices from the hippocampus. In the present study, we investigated whether there are regional differences in the hippocampus regarding this N-methyl-D-aspartate effect. In the absence of Mg2+, N-methyl-D-aspartate (10-200 mu M) induced the release of [H-3]norepinephrine from superfused minislices containing the dentate gyrus area or the CA(1)-CA(3) region of the hippocampus. Such N-methyl-D-aspartate effects on [H-3]norepinephrine release were significantly higher in the dentate gyrus than in the CA(1)-CA(3) area. The N-methyl-D-aspartate effects in both hippocampal areas were also reduced significantly by D-2-amino-5-phosphonovaleric acid (50 mu M), an antagonist of the N-methyl-D-aspartate receptor, and by tetrodotoxin, a blocker of the voltage-dependent Na+ channels. The extent of this reduction was the same in the dentate gyrus and the CA(1)-CA(3) area. Further experiments, conducted in the presence of Mg2+, demonstrated that N-methyl-D-aspartic acid increased K+-induced release of [H-3]norepinephrine from dentate gyrus minislices but not from the CA(1)-CA(3) area. The results are consistent with the existence of a higher density and/or different subtypes of N-methyl-D-aspartate receptors modulating [H-3]norepinephrine release in the dentate gyrus as compared with the CA(1)-CA(3) hippocampal area.
dc.fuente.origenWOS
dc.identifier.issn0006-2952
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98794
dc.identifier.wosidWOS:A1993MM43500014
dc.issue.numero11
dc.language.isoen
dc.pagina.final1987
dc.pagina.inicio1983
dc.revistaBiochemical pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleREGULATION OF [H-3] NOREPINEPHRINE RELEASE BY N-METHYL-D-ASPARTATE RECEPTORS IN MINISLICES FROM THE DENTATE GYRUS AND THE CA(1)-CA(3) AREA OF THE RAT HIPPOCAMPUS
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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