Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury

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dc.contributor.authorTroncoso, P
dc.contributor.authorOrtiz, AM
dc.contributor.authorDominguez, J
dc.contributor.authorKahan, BD
dc.date.accessioned2025-01-21T01:06:35Z
dc.date.available2025-01-21T01:06:35Z
dc.date.issued2005
dc.description.abstractIntroduction. Chronic allograft nephropathy is the main cause of graft loss. Although many factors are involved in its development, ischemia-reperfusion injury has received increasing attention as a risk determinant. In a previous study of syngeneic renal transplantation and ischemia, we demonstrated a protective effect of acute damage by FTY 720 and antisense oligonucleotides of ICAM-1 (Oligos). The purpose of the current study was to evaluate the impact of these agents on the development of chronic graft damage in the same model.
dc.description.abstractMethods. Lewis rat were used as donors and recipients. The harvested left kidney was kept in Collins solution for 2 hours. Recipient animals received treatment with FTY 720 or Oligos or saline. At 12 and 36 weeks after transplantation, creatinine clearance, GFR, proteinuria, and arterial blood pressure were recorded. Tissue from some animals were submitted for histological studies and quantification of mRNA TGF-beta 1.
dc.description.abstractResults. All groups showed decreased levels of GFR and creatinine clearence, but only the untreated animals showed significant deterioration compared to the pretransplant values (0.53 +/- 0.24 versus 0.21 +/- 0.24 at 36 weeks respectively; P < .05). Proteinuria was also significant in control animals at 36 weeks. Blood pressure showed a moderate increase in all groups. Histological analysis showed that treated animals had fewer signs of chronic damage according to the Banff score. All groups displayed slight increases in TGF-beta 1 without differences among them.
dc.description.abstractConclusions. In this model the use of FTY or antisense oligonucleotides of ICAM-1 were associated with less functional and morphological evidence of chronic graft damage secondary to an ischemia-reperfusion injury.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.transproceed.2005.10.093
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2005.10.093
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96184
dc.identifier.wosidWOS:000234412900034
dc.issue.numero10
dc.language.isoen
dc.pagina.final4288
dc.pagina.inicio4284
dc.revistaTransplantation proceedings
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUse of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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