Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis

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dc.contributor.authorCamargo, M. C.
dc.contributor.authorMurphy, G.
dc.contributor.authorKoriyama, C.
dc.contributor.authorPfeiffer, R. M.
dc.contributor.authorKim, W. H.
dc.contributor.authorHerrera-Goepfert, R.
dc.contributor.authorCorvalan, A. H.
dc.contributor.authorCarrascal, E.
dc.contributor.authorAbdirad, A.
dc.contributor.authorAnwar, M.
dc.contributor.authorHao, Z.
dc.contributor.authorKattoor, J.
dc.contributor.authorYoshiwara-Wakabayashi, E.
dc.contributor.authorEizuru, Y.
dc.contributor.authorRabkin, C. S.
dc.contributor.authorAkiba, S.
dc.date.accessioned2025-01-21T00:01:43Z
dc.date.available2025-01-21T00:01:43Z
dc.date.issued2011
dc.description.abstractBACKGROUND: Meta-analyses of the published literature indicate that about 9% of gastric cancers contain Epstein-Barr virus (EBV), with consistent and significant differences by sex and anatomic subsite. This study aimed to identify additional determinants of EBV positivity and their joint effects.
dc.description.abstractMETHODS: From 15 international populations with consistent laboratory testing for EBV, we pooled individual-level data for 5081 gastric cancer cases including information on age, sex, subsite, histologic type, diagnostic stage, geographic region, and period of diagnosis. First, we combined population-specific EBV prevalence estimates using random effects meta-analysis. We then aggregated individual-level data to estimate odds ratios of EBV positivity in relation to all variables, accounting for within-population clustering.
dc.description.abstractRESULTS: In unadjusted analyses, EBV positivity was significantly higher in males, young subjects, non-antral subsites, diffuse-type histology, and in studies from the Americas. Multivariable analyses confirmed significant associations with histology and region. Sex interacted with age (P = 0.003) and subsite (P = 0.002) such that male predominance decreased with age for both subsites. The positivity of EBV was not significantly associated with either stage or time period.
dc.description.abstractCONCLUSION: Aggregating individual-level data provides additional information over meta-analyses. Distinguishing histologic and geographic features as well as interactions among age, sex, and subsite further support classification of EBV-associated gastric cancer as a distinct aetiologic entity. British Journal of Cancer (2011) 105, 38-43. doi: 10.1038/bjc.2011.215 www.bjcancer.com Published online 7 June 2011 (C) 2011 Cancer Research UK
dc.description.funderNational Cancer Institute, National Institutes of Health
dc.fuente.origenWOS
dc.identifier.doi10.1038/bjc.2011.215
dc.identifier.issn0007-0920
dc.identifier.urihttps://doi.org/10.1038/bjc.2011.215
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95392
dc.identifier.wosidWOS:000292182400007
dc.issue.numero1
dc.language.isoen
dc.pagina.final43
dc.pagina.inicio38
dc.revistaBritish journal of cancer
dc.rightsacceso restringido
dc.subjectgastric cancer
dc.subjectEBV
dc.subjectprevalence
dc.subjectpooled analysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDeterminants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
dc.typeartículo
dc.volumen105
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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