Transcriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed

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dc.contributor.authorArenas, German A.
dc.contributor.authorSantander, Nicolas
dc.contributor.authorKrause, Bernardo J.
dc.date.accessioned2025-01-20T21:01:58Z
dc.date.available2025-01-20T21:01:58Z
dc.date.issued2022
dc.description.abstractUmbilical and placental vessels and endothelial cells (EC) are common models to study placental function and vascular programming. Arterio-venous differences are present in the umbilical endothelium; however, the heterogeneity of small placental vessels and the expression of potential micro- vs. macro-vascular (MMV) markers are poorly described. Here, we performed a meta-analysis of transcriptomic and DNA methylation data from placental and umbilical EC. Expression and methylation profiles were compared using hierarchical clustering, dimensionality reduction (i.e., tSNE, MDS, and PHATE), and enrichment analysis to determine the occurrence of arterio-venous (AVH) and micro-macro heterogeneity (MMH). CpG sites correlated with gene expression of transcriptional markers of MMH and AVH were selected by Lasso regression and used for EC discrimination. General transcriptional profile resulted in clear segregation of EC by their specific origin. MM and AVH grouping were also observed when microvascular markers were applied. Altogether, this meta-analysis provides cogent evidence regarding the transcriptional and epigenomic profiles that differentiate among EC, proposing novel markers to define phenotypes based on MM levels.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms231911873
dc.identifier.eissn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms231911873
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92988
dc.identifier.wosidWOS:000867734800001
dc.issue.numero19
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectendothelial
dc.subjectplacenta
dc.subjectumbilical
dc.subjectepigenetics
dc.subjectphenotypic heterogeneity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTranscriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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