Alcohol-related liver disease: A global perspective

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dc.contributor.authorNarro, Graciela Elia Castro
dc.contributor.authorDiaz, Luis Antonio
dc.contributor.authorOrtega, Eric Kauffman
dc.contributor.authorGarin, Maria Fernanda Bautista
dc.contributor.authorReyes, Eira Cerda
dc.contributor.authorDelfin, Pindaro Sebastian Martinez
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorBataller, Ramon
dc.date.accessioned2025-01-20T16:08:22Z
dc.date.available2025-01-20T16:08:22Z
dc.date.issued2024
dc.description.abstractAlcohol-associated liver disease (ALD) represents one of the deadliest yet preventable consequences of excessive alcohol use. It represents 5.1 % of the global burden of disease, mainly involving the productive-age population (15-44 years) and leading to an increased mortality risk from traffic road injuries, suicide, violence, cardiovascular disease, neoplasms, and liver disease, among others, accounting for 5.3 % of global deaths. Daily alcohol consumption, binge drinking (BD), and heavy episodic drinking (HED) are the patterns associated with a higher risk of developing ALD. The escalating global burden of ALD, even exceeding what was predicted, is the result of a complex interaction between the lack of public policies that regulate alcohol consumption, low awareness of the scope of the disease, late referral to specialists, underuse of available medications, insufficient funds allocated to ALD research, and non-predictable events such as the COVID-19 pandemic, where increases of up to 477 % in online alcohol sales were registered in the United States. Early diagnosis, referral, and treatment are pivotal to achieving the therapeutic goal in patients with alcohol use disorder (AUD) and ALD, where complete alcohol abstinence and prevention of alcohol relapse are expected to enhance overall survival. This can be achieved through a combination of cognitive behavioral, motivational enhancement and pharmacological therapy. Furthermore, the appropriate use of available pharmacological therapy and implementation of public policies that comprehensively address this disease will make a real difference. (c) 2024 Fundaci & oacute;n Clinica M & eacute;dica Sur, A.C. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.aohep.2024.101499
dc.identifier.issn1665-2681
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2024.101499
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90073
dc.identifier.wosidWOS:001316521200001
dc.issue.numero5
dc.language.isoen
dc.revistaAnnals of hepatology
dc.rightsacceso restringido
dc.subjectAlcohol use disorder
dc.subjectAlcohol-associated liver disease
dc.subjectAlcohol-related cirrhosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlcohol-related liver disease: A global perspective
dc.typeartículo
dc.volumen29
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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