The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer

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dc.contributor.authorFuente López , Marjorie de la
dc.contributor.authorLandskron Ramos, Glauben Tamara
dc.contributor.authorParada, Daniela
dc.contributor.authorDubois Camacho, Karen
dc.contributor.authorSimian, Daniela
dc.contributor.authorMartinez, Jalilie Maripaz
dc.contributor.authorRomero Vera, Diego Ignacio
dc.contributor.authorRoa Strauch, Juan Carlos Enrique
dc.contributor.authorChahuán, Isidora
dc.contributor.authorGutiérrez, Rocío
dc.contributor.authorLopez K, Francisco
dc.contributor.authorÁlvarez, Karin
dc.contributor.authorKronberg, Udo
dc.contributor.authorLópez, Sebastian
dc.contributor.authorSanguinett, Antonella
dc.contributor.authorMoreno, Natalia
dc.contributor.authorAbedrapo, Mario
dc.contributor.authorGonzález, María-Julieta
dc.contributor.authorQuera, Rodrigo
dc.contributor.authorHermoso R., Marcela A.
dc.date.accessioned2026-01-07T14:10:08Z
dc.date.available2026-01-07T14:10:08Z
dc.date.issued2018
dc.description.abstractA complex network of chemokines can influence cancer progression with the recruitment and activation of hematopoietic cells, including macrophages to the supporting tumor stroma promoting carcinogenesis and metastasis. The aim of this study was to investigate the relation between tissue and plasma chemokine levels involved in macrophage recruitment with tumor-associated macrophage profile markers and clinicopathological features such as tumor–node–metastases stage, desmoplasia, tumor necrosis factor-α, and vascular endothelial growth factor plasma content. Plasma and tumor/healthy mucosa were obtained from Chilean patients undergoing colon cancer surgery. Chemokines were evaluated from tissue lysates (CCL2, CCL3, CCL4, CCL5, and CX3CL1) by Luminex. Statistical analysis was performed using Wilcoxon match-paired test (p < 0.05). Macrophage markers (CD68, CD163, and iNOS) were evaluated by immunohistochemistry samples derived from colorectal cancer patients. Correlation analysis between chemokines and macrophage markers and clinicopathological features were performed using Spearman’s test. Plasmatic levels of chemokines and inflammatory mediators’ vascular endothelial growth factor and tumor necrosis factor-α were evaluated by Luminex. Tumor levels of CCL2 (mean ± standard deviation = 530.1 ± 613.9 pg/mg), CCL3 (102.7 ± 106.0 pg/mg), and CCL4 (64.98 ± 48.09 pg/mg) were higher than those found in healthy tissue (182.1 ± 116.5, 26.79 ± 22.40, and 27.06 ± 23.69 pg/mg, respectively p < 0.05). The tumor characterization allowed us to identify a positive correlation between CCL4 and the pro-tumor macrophages marker CD163 (p = 0.0443), and a negative correlation of iNOS with desmoplastic reaction (p = 0.0467). Moreover, we identified that tumors with immature desmoplasia have a higher CD163 density compared to those with a mature/intermediated stromal tissue (p = 0.0288). Plasmatic CCL4 has shown a positive correlation with inflammatory mediators (tumor necrosis factor-α and vascular endothelial growth factor) that have previously been associated with poor prognosis in patients. In conclusion High expression of CCL4 in colon cancer could induce the infiltration of tumor-associated macrophages and specifically a pro-tumor macrophage profile (CD163+ cells). Moreover, plasmatic chemokines could be considered inflammatory mediators associated to CRC progression as well as tumor necrosis factor-α and vascular endothelial growth factor. These data reinforce the idea of chemokines as potential therapeutic targets or biomarker in CRC.
dc.fechaingreso.objetodigital2026-01-07
dc.format.extent12 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1177/1010428318810059
dc.identifier.eissn1423-0380
dc.identifier.issn1010-4283
dc.identifier.pubmedid30419802
dc.identifier.scopusidSCOPUS_ID:85056325625
dc.identifier.urihttps://doi.org/10.1177/1010428318810059
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107560
dc.information.autorucFacultad de Ciencias Biológicas; De La Fuente López, Marjorie Katherine; 0000-0003-0577-7604; 127047
dc.information.autorucEscuela de Medicina; Romero Vera, Diego Ignacio; 0009-0004-1543-4319; 1012471
dc.information.autorucEscuela de Medicina; Roa Strauch, Juan Carlos Enrique; 0000-0001-8313-8774; 84743
dc.information.autorucEscuela de Medicina; Kronberg, Udo; S/I; 123403
dc.issue.numero11
dc.nota.accesocontenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaTumor Biology
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectColorectal cancer
dc.subjectTumor microenvironment
dc.subjectChemokines
dc.subjectMmacrophages
dc.subject.ods15 Life on land
dc.subject.ods06 Clean water and sanitation
dc.subject.odspa15 Vida de ecosistemas terrestres
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleThe relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer
dc.typeartículo
dc.volumen40
sipa.codpersvinculados1054685
sipa.codpersvinculados127047
sipa.codpersvinculados1012471
sipa.codpersvinculados84743
sipa.codpersvinculados123403
sipa.trazabilidadConveris;20-07-2021
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