Novel Risk Associations between microRNA Polymorphisms and Gastric Cancer in a Chilean Population

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dc.article.number467
dc.catalogadoraba
dc.contributor.authorLanderos, Natalia
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorMusleh, Maher
dc.contributor.authorQuinones, Luis A.
dc.contributor.authorVarela, Nelson M.
dc.contributor.authorGonzalez Hormazabal, Patricio
dc.date.accessioned2024-06-10T21:25:33Z
dc.date.available2024-06-10T21:25:33Z
dc.date.issued2022
dc.description.abstractGastric cancer (GC) is the fifth leading cause of cancer deaths in the world, with variations across geographical regions and ethnicities. Emerging evidence indicates that miRNA expression is dysregulated in GC and its polymorphisms may contribute to these variations, which has yet to be explored in Latin American populations. In a case-control study of 310 GC patients and 311 healthy donors from Chile, we assessed the association of 279 polymorphisms in 242 miRNA genes. Two novel polymorphisms were found to be associated with GC: rs4822739:C>G (miR-548j) and rs701213:T>C (miR-4427). Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. The polymorphisms rs6149511:T> TGAAGGGCTCCA (miR-6891), rs404337:G>A (miR-8084), and rs1439619:T>G (miR-3175) were identified among H.pylori-infected GC patients and rs7500280:T>C (miR-4719) and rs1439619:T>G (miR-3175) were found among H. pylori cagPAI+ infected GC cases. Prediction analysis suggests that seven polymorphisms could alter the secondary structure of the miRNA, and the other one is located in the seed region of miR-938. Targets of miRNAs are enriched in GC pathways, suggesting a possible biological effect. In this study, we identified seven novel associations and replicated one previously described in Caucasian population. These findings contribute to the understanding of miRNA genetic polymorphisms in the GC pathogenesis.
dc.fechaingreso.objetodigital2024-06-12
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms23010467
dc.identifier.eissn1422-0067
dc.identifier.pubmedidMEDLINE:35008894
dc.identifier.urihttps://doi.org/10.3390/ijms23010467
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86717
dc.identifier.wosidWOS:000752845000001
dc.information.autorucEscuela de Medicina; Corvalán R., Alejandro; 0000-0001-5492-3853; 63885
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectGastric cancer
dc.subjectmiRNA
dc.subjectPolymorphism
dc.subjectHelicobacter pylori
dc.subjectcag pathogenicity island
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNovel Risk Associations between microRNA Polymorphisms and Gastric Cancer in a Chilean Population
dc.typeartículo
dc.volumen23
sipa.codpersvinculados63885
sipa.trazabilidadORCID;2024-06-03
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