Evidence of autophagic vesicles in a patient with Lisch corneal dystrophy

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dc.contributor.authorGrau, Arturo E.
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorZoroquiain, Pablo
dc.contributor.authorGonzalez, Pablo A.
dc.contributor.authorKhaliliyeh, Daniela
dc.contributor.authorMorselli, Eugenia
dc.contributor.authorCortes, Dennis
dc.date.accessioned2025-01-23T19:53:31Z
dc.date.available2025-01-23T19:53:31Z
dc.date.issued2020
dc.description.abstractLisch corneal dystrophy is a rare corneal disease characterized by the distinctive feature of highly vacuolated cells. Although this feature is important, the nature of these vacuoles within corneal cells remains unknown. Here, we sought to analyze corneal cells from a patient diagnosed with Lisch dystrophy to characterize the vacuoles within these cells. Analyses using histopathology examination, confocal microscopy, and transmission electron microscopy were all consistent with previous descriptions of Lisch cells. Importantly, the vacuoles within these cells appeared to be autophagosomes and autolysosomes, and could be stained with an anti-microtubule-associated protein 1A/1B-light chain 3 (LC3) antibody. Taken together, these findings indicate that the vacuoles we observed within superficial corneal cells of a patient with Lisch corneal dystrophy constituted autophagosomes and autolysosomes; this finding has not been previously reported and suggests a need for further analyses to define the role of autophagy in this ocular disease.
dc.fuente.origenWOS
dc.identifier.doi10.5935/0004-2749.20200027
dc.identifier.eissn1678-2925
dc.identifier.issn0004-2749
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20200027
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100661
dc.identifier.wosidWOS:000519597600012
dc.issue.numero2
dc.language.isoen
dc.pagina.final148
dc.pagina.inicio146
dc.revistaArquivos brasileiros de oftalmologia
dc.rightsacceso restringido
dc.subjectAutophagy
dc.subjectCorneal dystrophies
dc.subjecthereditary
dc.subjectCorneal opacity
dc.subjectVacuoles/pathology
dc.subjectHumans
dc.titleEvidence of autophagic vesicles in a patient with Lisch corneal dystrophy
dc.typeartículo
dc.volumen83
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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