Profile of adult patients hospitalized with COVID-19 before and after introduction of SARS-CoV-2 vaccines

Simple item page
dc.contributor.authorPotin, Marcela
dc.contributor.authorAljaro, Sofia
dc.contributor.authorLopez, Sofia
dc.contributor.authorUauy, Olga
dc.contributor.authorCifuentes, Constanza
dc.contributor.authorCerda, Jaime
dc.contributor.authorValenzuela, Daniel
dc.date.accessioned2025-01-20T17:15:14Z
dc.date.available2025-01-20T17:15:14Z
dc.date.issued2023
dc.description.abstractBackground: During the COVID-19 pandemic, the early prioriti-zation of SARS-CoV-2 vaccines for older adults may have affected the characteristics of hospitalized COVID-19 patients over time. Aim: To compare the clinical characteristics and outcomes of adult patients admitted for COVID-19 before (PER1) and after (PER2) the initiation of mass vaccination for SARS-CoV-2. Methods: Data on age, gender, comorbidities, complications, and outcomes of adult patients hospitalized for COVID-19 in a private clinic of Santiago, Chile, were collected. Scores for COVID-19 severity and nutritional risk were calculated. Results: In PER2, patients were younger but had similar comorbidities, except for a higher prevalence of overweight and obesity compared to PER1. Unvaccinated COVID-19 patients in PER2 required more invasive ventilatory support (38.9% vs. 14.3%, p = 0.03) and had a higher severity score (six) than vaccinated patients (five, p = 0.048). The variables that best predicted mortality were age > 60 years (OR 28,995) and the presence of nutritional risk (OR 5,246). Discussion: Changes in the profile and outcomes of hospita-lized patients during the COVID-19 pandemic are associated with the prioritization of SARS-CoV-2 vaccines and their protective effect in and disease in older adults.
dc.fuente.origenWOS
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91311
dc.identifier.wosidWOS:001125996800013
dc.issue.numero5
dc.language.isoen
dc.pagina.final480
dc.pagina.inicio472
dc.revistaRevista chilena de infectologia
dc.rightsacceso restringido
dc.subjectCOVID-19 vaccines
dc.subjectcomorbidities
dc.subjectadults
dc.subjectmortality
dc.subjectnutritional risk score
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleProfile of adult patients hospitalized with COVID-19 before and after introduction of SARS-CoV-2 vaccines
dc.typeartículo
dc.volumen40
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas