"Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress

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dc.contributor.authorRivera, Daniela S.
dc.contributor.authorLindsay, Carolina B.
dc.contributor.authorOliva, Carolina A.
dc.contributor.authorBozinovic, Francisco
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-20T22:19:06Z
dc.date.available2025-01-20T22:19:06Z
dc.date.issued2021
dc.description.abstractLoneliness affects group-living mammals triggering a cascade of stress-dependent physiological disorders. Indeed, social isolation stress is a major risk factor for several neuropsychiatric disorders including anxiety and depression. Furthermore, social isolation has a negative impact on health and fitness. However, the neurobiological consequences of long-term chronic social isolation stress (LTCSIS) manifested during the adulthood of affected individuals are not fully understood. Our study assessed the impact of LTCSIS and social buffering (re-socialization) on the behavioural performance and social-affective brain-related proteins in diurnal, social, and long-lived Octodon degus (degus). Thereby, anxiety-like and social behaviour, and social recognition memory were assessed in male and female animals subjected to a variety of stress-inducing treatments applied from postnatal and post-weaning until their adulthood. Additionally, we evaluated the relationship among LTCSIS, Oxytocin levels (OXT), and OXT-Ca2+-signalling proteins in the hypothalamus, the hippocampus, and the prefrontal cortex. Our findings suggest that LTCSIS induces anxiety like-behaviour and impairs social novelty preference whereas sociability is unaffected. On the other hand, re-socialization can revert both isolation-induced anxiety and social memory impairment. However, OXT and its signalling remained reduced in the abovementioned brain areas, suggesting that the observed changes in OXT-Ca2+ pathway proteins were permanent in male and female degus. Based on these findings, we conclude degus experience social stress differently, suggesting the existence of sex-related mechanisms to cope with specific adaptive challenges.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ynstr.2020.100289
dc.identifier.issn2352-2895
dc.identifier.urihttps://doi.org/10.1016/j.ynstr.2020.100289
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94587
dc.identifier.wosidWOS:000663082200003
dc.language.isoen
dc.revistaNeurobiology of stress
dc.rightsacceso restringido
dc.subjectOctodon degus
dc.subjectChronic stress
dc.subjectAnxiety-like behaviour
dc.subjectmemory-Oxytocin-Ca2+ signalling
dc.subjectRe-socialization
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title"Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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