Intra-articular treatment with corticosteroids increases apoptosis in human rotator cuff tears

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dc.contributor.authorPablo Ramirez, Juan
dc.contributor.authorBonati-Richardson, Francesca
dc.contributor.authorPia Garcia, Maria
dc.contributor.authorHidalgo, Christian
dc.contributor.authorStoore, Caroll
dc.contributor.authorLiendo, Rodrigo
dc.contributor.authorSoza, Francisco
dc.contributor.authorLanderer, Eduardo
dc.contributor.authorParedes, Rodolfo
dc.date.accessioned2025-01-23T21:16:01Z
dc.date.available2025-01-23T21:16:01Z
dc.date.issued2019
dc.description.abstractPurpose: The aim of this study is to evaluate in vivo the level of apoptosis in human rotator cuff tears and the relationship it might have with tendon degeneration. Methods: Rotator cuff biopsies from 19 male and female patients, ages between 38 and 68 years, with and without previous corticosteroid infiltrations were collected via arthroscopy. Biopsies from seven patients with healthy rotator cuffs were used as a control group. An in situ terminal deoxynucleotidyl transferase dUTP nick end labeling assay was performed to detect the level of apoptosis, which was expressed as a percentage of apoptotic cells (PAC). Results: PAC in patients with corticosteroid infiltrations was 76.97 +/- 16.99 in all tendon rupture zones, in non-infiltrated patients was 35.89 +/- 22.96, whereas in control patients was 14.48 +/- 8.15. Likewise, the tendency of PAC reveals that apoptosis in control and non-infiltrated groups was different and dispersed in all tear zones; while in corticosteroid treated patients, the tendency was similar in all rupture sites. Conclusions: This investigation leads us to conclude that the administration of corticosteroid is associated with a higher amount of apoptosis at the insertion site of the rotator cuff (rupture edge).
dc.fuente.origenWOS
dc.identifier.doi10.1080/03008207.2018.1501040
dc.identifier.eissn1607-8438
dc.identifier.issn0300-8207
dc.identifier.urihttps://doi.org/10.1080/03008207.2018.1501040
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101108
dc.identifier.wosidWOS:000465125100008
dc.issue.numero3
dc.language.isoen
dc.pagina.final290
dc.pagina.inicio283
dc.revistaConnective tissue research
dc.rightsacceso restringido
dc.subjectApoptosis
dc.subjectcorticosteroid infiltration
dc.subjectrotator cuff
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntra-articular treatment with corticosteroids increases apoptosis in human rotator cuff tears
dc.typeartículo
dc.volumen60
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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