MOGAD: A Shifting Landscape—From Pathogenesis to Personalised Management, Global Perspectives and Latin American Insights

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dc.catalogadorjlo
dc.contributor.authorCiampi, Ethel
dc.date.accessioned2025-10-02T18:37:46Z
dc.date.available2025-10-02T18:37:46Z
dc.date.issued2025
dc.description.abstractMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has emerged as a distinct autoimmune demyelinating disorder, characterised by clinical, radiological, and immunopathological features that differentiate it from Multiple Sclerosis (MS) and AQP4+ neuromyelitis optica spectrum disorder (AQP4+NMOSD). This review provides a comprehensive synthesis of the evolving landscape of MOGAD, from its immunopathogenesis and diagnostic criteria to treatment strategies and global epidemiological insights. We explore the role of MOG-IgG antibodies in disease mechanisms, the utility of emerging biomarkers, and the prognostic value of tools like clinical scores or longitudinal MOG-IgG assessment. Special attention is given to regional disparities, with a focus on Latin America, highlighting diagnostic delays, access inequities, and unique clinical phenotypes. We also examine the limitations of current evidence, including gaps in long-term longitudinal follow-up and variability in diagnostic testing. Finally, we discuss global collaborative efforts and clinical trials that are shaping the future of personalised care in MOGAD. As the field advances, integrating biomarker-driven monitoring, equitable access to therapies, and regionally adapted guidelines will be essential to improving outcomes for patients worldwide.
dc.format.extent28 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/biomedicines13102344
dc.identifier.issn2227-9059
dc.identifier.urihttps://doi.org/10.3390/biomedicines13102344
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105884
dc.information.autorucEscuela de Medicina; Ciampi Díaz, Ethel Leslie; 0000-0002-7330-5433; 132794
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaBiomedicines
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMOGAD: A Shifting Landscape—From Pathogenesis to Personalised Management, Global Perspectives and Latin American Insights
dc.typeartículo
dc.volumen13
sipa.codpersvinculados132794
sipa.trazabilidadORCID;2025-09-29
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